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Biosynthesis of glycosylated derivatives of tylosin in Streptomyces venezuelae

Title
Biosynthesis of glycosylated derivatives of tylosin in Streptomyces venezuelae
Authors
Han A.R.Park S.R.Park J.W.Lee E.Y.Kim D.-M.Kim B.-G.Yoon Y.J.
Ewha Authors
윤여준박제원
SCOPUS Author ID
윤여준scopus
Issue Date
2011
Journal Title
Journal of Microbiology and Biotechnology
ISSN
1017-7825JCR Link
Citation
vol. 21, no. 6, pp. 613 - 616
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Streptomyces venezuelae YJ028, bearing a deletion of the entire biosynthetic gene cluster encoding the pikromycin polyketide synthases and desosamine biosynthetic enzymes, was used as a bioconversion system for combinatorial biosynthesis of glycosylated derivatives of tylosin. Two engineered deoxysugar biosynthetic pathways for the biosynthesis of TDP-3-O-demethyl-D-chalcose or TDP-Lrhamnose in conjunction with the glycosyltransferaseauxiliary protein pair DesVII/DesVIII were expressed in a S. venezuelae YJ028 mutant strain. Supplementation of each mutant strain capable of producing TDP-3-O-demethyl- D-chalcose or TDP-L-rhamnose with tylosin aglycone tylactone resulted in the production of the 3-O-demethyl- D-chalcose, D-quinovose, or L-rhamnose-glycosylated tylactone. © The Korean Society for Microbiology and Biotechnology.
DOI
10.4014/jmb.1103.03032
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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