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Adiposity and the risk of colorectal adenomatous polyps: A meta-analysis

Title
Adiposity and the risk of colorectal adenomatous polyps: A meta-analysis
Authors
Lee Y.J.Myung S.-K.Cho B.Park B.-J.Park J.H.Ju W.Park M.-S.Choi J.-H.
Ewha Authors
주웅
SCOPUS Author ID
주웅scopus
Issue Date
2011
Journal Title
Cancer Causes and Control
ISSN
0957-5243JCR Link
Citation
vol. 22, no. 7, pp. 1021 - 1035
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Objective: The findings from epidemiological studies addressing the association between adiposity and the risk of colorectal adenomatous polyps are inconsistent. We performed a meta-analysis of epidemiological studies including cross-sectional, case-control, and cohort studies. Methods: We searched PubMed and EMBASE in June, 2010. All searched articles were reviewed and selected independently by two evaluators according to pre-determined selection criteria. Results: We included 25 studies (nine cross-sectional studies, eleven case-control studies, and five prospective cohort studies) that comprised a total of 300,671 participants and 20,903 cases in the final analysis. When all studies were pooled, the odds ratio (OR) or relative risk (RR) of adiposity and abdominal adiposity for colorectal adenomatous polyp risk was 1.43 (95% confidence interval (CI) 1.23-1.67; n = 22) and 1.42 (95% CI 1.30-1.56; n = 12), respectively. Similarly, an increased risk of colorectal adenomatous polyps was observed in most of the subgroup meta-analyses. Conclusions: Overall, we found that adiposity and abdominal adiposity significantly increased the risk of colorectal adenomatous polyps in a meta-analysis of epidemiological studies. © 2011 Springer Science+Business Media B.V.
DOI
10.1007/s10552-011-9777-9
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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