Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정낙신 | - |
dc.contributor.author | 최원준 | - |
dc.date.accessioned | 2016-08-28T12:08:47Z | - |
dc.date.available | 2016-08-28T12:08:47Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0253-2964 | - |
dc.identifier.other | OAK-7654 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221685 | - |
dc.description.abstract | Homologated analogues 3a and 3b of potent and selective A3 adenosine receptor ligands, IB-MECA and dimethyl-IB-MECA were synthesized from commercially available 1-O-acetyl-2,3,5-tri-O-benzoyl-β-Dribofuranose (4) via Co2(CO)8-catalyzed siloxymethylation as a key step. Unfortunately, homologated analogues 3a and 3b did not show significant binding affinities at three subtypes of adenosine receptors, indicating that free rotation, resulting from homologation, induced unfavorable interactions in the binding site of the receptor maybe due to the presence of many conformations. | - |
dc.language | English | - |
dc.title | Synthesis and binding affinity of homologated adenosine analogues as A3 adenosine receptor ligands | - |
dc.type | Article | - |
dc.relation.issue | 5 | - |
dc.relation.volume | 32 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 1620 | - |
dc.relation.lastpage | 1624 | - |
dc.relation.journaltitle | Bulletin of the Korean Chemical Society | - |
dc.identifier.doi | 10.5012/bkcs.2011.32.5.1620 | - |
dc.identifier.wosid | WOS:000291171000034 | - |
dc.identifier.scopusid | 2-s2.0-79957519264 | - |
dc.author.google | Lee H.W. | - |
dc.author.google | Choi W.J. | - |
dc.author.google | Jacobson K.A. | - |
dc.author.google | Jeong L.S. | - |
dc.contributor.scopusid | 정낙신(16028528200) | - |
dc.contributor.scopusid | 최원준(55732412300;57211762651) | - |
dc.date.modifydate | 20230627112239 | - |