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dc.contributor.author윤여준-
dc.date.accessioned2016-08-28T12:08:46Z-
dc.date.available2016-08-28T12:08:46Z-
dc.date.issued2011-
dc.identifier.issn0163-3864-
dc.identifier.otherOAK-7651-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/221682-
dc.description.abstractA new reduced hydroxamate, 2,3-dihydrotrichostatin A, was created from trichostatin A by employing a recombinant strain of Streptomyces venezuelae as a microbial catalyst. Compared with trichostatin A, 2,3-dihydrotrichostatin A showed similar antifungal activity against Saccharomyces cerevisiae, but, interestingly, approximately twice the cytostatic activity against human small-cell lung cancer cells. The production of 2,3-dihydrotrichostatin A via microbial biotransformation demonstrates that the regiospecific and substrate-flexible hydrogenation by S. venezuelae provides a new approach for creating natural product analogues with improved bioactive properties. (Chemical Equation Presented). © 2011 The American Chemical Society and American Society of Pharmacognosy.-
dc.languageEnglish-
dc.titleMicrobial transformation of trichostatin A to 2,3-dihydrotrichostatin A-
dc.typeArticle-
dc.relation.issue5-
dc.relation.volume74-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage1272-
dc.relation.lastpage1274-
dc.relation.journaltitleJournal of Natural Products-
dc.identifier.doi10.1021/np1006718-
dc.identifier.wosidWOS:000291127900053-
dc.identifier.scopusid2-s2.0-79957853310-
dc.author.googlePark J.W.-
dc.author.googlePark S.R.-
dc.author.googleHan A.R.-
dc.author.googleBan Y.-H.-
dc.author.googleYoo Y.J.-
dc.author.googleKim E.J.-
dc.author.googleKim E.-
dc.author.googleYoon Y.J.-
dc.contributor.scopusid윤여준(7402126465)-
dc.date.modifydate20210708161345-
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자연과학대학 > 화학·나노과학전공 > Journal papers
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