Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤여준 | - |
dc.date.accessioned | 2016-08-28T12:08:46Z | - |
dc.date.available | 2016-08-28T12:08:46Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0163-3864 | - |
dc.identifier.other | OAK-7651 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221682 | - |
dc.description.abstract | A new reduced hydroxamate, 2,3-dihydrotrichostatin A, was created from trichostatin A by employing a recombinant strain of Streptomyces venezuelae as a microbial catalyst. Compared with trichostatin A, 2,3-dihydrotrichostatin A showed similar antifungal activity against Saccharomyces cerevisiae, but, interestingly, approximately twice the cytostatic activity against human small-cell lung cancer cells. The production of 2,3-dihydrotrichostatin A via microbial biotransformation demonstrates that the regiospecific and substrate-flexible hydrogenation by S. venezuelae provides a new approach for creating natural product analogues with improved bioactive properties. (Chemical Equation Presented). © 2011 The American Chemical Society and American Society of Pharmacognosy. | - |
dc.language | English | - |
dc.title | Microbial transformation of trichostatin A to 2,3-dihydrotrichostatin A | - |
dc.type | Article | - |
dc.relation.issue | 5 | - |
dc.relation.volume | 74 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 1272 | - |
dc.relation.lastpage | 1274 | - |
dc.relation.journaltitle | Journal of Natural Products | - |
dc.identifier.doi | 10.1021/np1006718 | - |
dc.identifier.wosid | WOS:000291127900053 | - |
dc.identifier.scopusid | 2-s2.0-79957853310 | - |
dc.author.google | Park J.W. | - |
dc.author.google | Park S.R. | - |
dc.author.google | Han A.R. | - |
dc.author.google | Ban Y.-H. | - |
dc.author.google | Yoo Y.J. | - |
dc.author.google | Kim E.J. | - |
dc.author.google | Kim E. | - |
dc.author.google | Yoon Y.J. | - |
dc.contributor.scopusid | 윤여준(7402126465) | - |
dc.date.modifydate | 20210708161345 | - |