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Microbial transformation of trichostatin A to 2,3-dihydrotrichostatin A
- Microbial transformation of trichostatin A to 2,3-dihydrotrichostatin A
- Park J.W.; Park S.R.; Han A.R.; Ban Y.-H.; Yoo Y.J.; Kim E.J.; Kim E.; Yoon Y.J.
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- Journal of Natural Products
- vol. 74, no. 5, pp. 1272 - 1274
- SCI; SCIE; SCOPUS
- A new reduced hydroxamate, 2,3-dihydrotrichostatin A, was created from trichostatin A by employing a recombinant strain of Streptomyces venezuelae as a microbial catalyst. Compared with trichostatin A, 2,3-dihydrotrichostatin A showed similar antifungal activity against Saccharomyces cerevisiae, but, interestingly, approximately twice the cytostatic activity against human small-cell lung cancer cells. The production of 2,3-dihydrotrichostatin A via microbial biotransformation demonstrates that the regiospecific and substrate-flexible hydrogenation by S. venezuelae provides a new approach for creating natural product analogues with improved bioactive properties. (Chemical Equation Presented). © 2011 The American Chemical Society and American Society of Pharmacognosy.
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