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Microbial transformation of trichostatin A to 2,3-dihydrotrichostatin A

Title
Microbial transformation of trichostatin A to 2,3-dihydrotrichostatin A
Authors
Park J.W.Park S.R.Han A.R.Ban Y.-H.Yoo Y.J.Kim E.J.Kim E.Yoon Y.J.
Ewha Authors
윤여준
SCOPUS Author ID
윤여준scopus
Issue Date
2011
Journal Title
Journal of Natural Products
ISSN
0163-3864JCR Link
Citation
vol. 74, no. 5, pp. 1272 - 1274
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A new reduced hydroxamate, 2,3-dihydrotrichostatin A, was created from trichostatin A by employing a recombinant strain of Streptomyces venezuelae as a microbial catalyst. Compared with trichostatin A, 2,3-dihydrotrichostatin A showed similar antifungal activity against Saccharomyces cerevisiae, but, interestingly, approximately twice the cytostatic activity against human small-cell lung cancer cells. The production of 2,3-dihydrotrichostatin A via microbial biotransformation demonstrates that the regiospecific and substrate-flexible hydrogenation by S. venezuelae provides a new approach for creating natural product analogues with improved bioactive properties. (Chemical Equation Presented). © 2011 The American Chemical Society and American Society of Pharmacognosy.
DOI
10.1021/np1006718
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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