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dc.contributor.author이경림*
dc.contributor.author권영주*
dc.contributor.author김미영*
dc.date.accessioned2016-08-28T12:08:44Z-
dc.date.available2016-08-28T12:08:44Z-
dc.date.issued2011*
dc.identifier.issn0946-2716*
dc.identifier.otherOAK-7627*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/221663-
dc.description.abstractTranslationally controlled tumor protein (TCTP) is believed to be involved in a variety of inflammatory processes: secretion of histamine and cytokines such as IL-4, IL-8, IL-13, and granulocyte/macrophage colony-stimulating factor; chemoattraction for eosinophils; augmentation of B cell proliferation; and immunoglobulin production, thereby potentially regulating allergic phenomena. In a previous study, we showed that the cytokine-releasing activity of extracellular TCTP is generated only when TCTP dimerizes via the intermolecular disulfide bond of NH2-terminal truncated TCTP implying that the dimerized TCTP (dTCTP) promotes the inflammatory phenomena. Modulation of dTCTP, thus, may offer a strategy for the treatment of chronic allergic diseases. In this study, we searched for dTCTP-binding peptides (dTBPs) by screening a phage-displayed 7-mer peptide library. We identified one peptide in the library, designated as dTBP2, which showed higher affinity to dTCTP than to full-length, monomeric TCTP. dTBP2 inhibited the induction of IL-8 by dTCTP from BEAS-2B cells. dTBP2 also reduced symptom score and eosinophil infiltration in a mouse rhinitis model. This study suggests that the dTBP2 binding to dTCTP modulates the release of inflammatory mediators of dTCTP. This result may provide a rational strategy for the treatment of allergic diseases. © 2011 Springer-Verlag.*
dc.languageEnglish*
dc.titleA peptide binding to dimerized translationally controlled tumor protein modulates allergic reactions*
dc.typeArticle*
dc.relation.issue6*
dc.relation.volume89*
dc.relation.indexSCI*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.startpage603*
dc.relation.lastpage610*
dc.relation.journaltitleJournal of Molecular Medicine*
dc.identifier.doi10.1007/s00109-011-0740-8*
dc.identifier.wosidWOS:000290817600008*
dc.identifier.scopusid2-s2.0-79959955190*
dc.author.googleKim M.*
dc.author.googleChung J.*
dc.author.googleLee C.*
dc.author.googleJung J.*
dc.author.googleKwon Y.*
dc.author.googleLee K.*
dc.contributor.scopusid이경림(7501517435)*
dc.contributor.scopusid권영주(12446435600)*
dc.date.modifydate20240301081003*
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약학대학 > 약학과 > Journal papers
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