Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이경림 | * |
dc.contributor.author | 권영주 | * |
dc.contributor.author | 김미영 | * |
dc.date.accessioned | 2016-08-28T12:08:44Z | - |
dc.date.available | 2016-08-28T12:08:44Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 0946-2716 | * |
dc.identifier.other | OAK-7627 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221663 | - |
dc.description.abstract | Translationally controlled tumor protein (TCTP) is believed to be involved in a variety of inflammatory processes: secretion of histamine and cytokines such as IL-4, IL-8, IL-13, and granulocyte/macrophage colony-stimulating factor; chemoattraction for eosinophils; augmentation of B cell proliferation; and immunoglobulin production, thereby potentially regulating allergic phenomena. In a previous study, we showed that the cytokine-releasing activity of extracellular TCTP is generated only when TCTP dimerizes via the intermolecular disulfide bond of NH2-terminal truncated TCTP implying that the dimerized TCTP (dTCTP) promotes the inflammatory phenomena. Modulation of dTCTP, thus, may offer a strategy for the treatment of chronic allergic diseases. In this study, we searched for dTCTP-binding peptides (dTBPs) by screening a phage-displayed 7-mer peptide library. We identified one peptide in the library, designated as dTBP2, which showed higher affinity to dTCTP than to full-length, monomeric TCTP. dTBP2 inhibited the induction of IL-8 by dTCTP from BEAS-2B cells. dTBP2 also reduced symptom score and eosinophil infiltration in a mouse rhinitis model. This study suggests that the dTBP2 binding to dTCTP modulates the release of inflammatory mediators of dTCTP. This result may provide a rational strategy for the treatment of allergic diseases. © 2011 Springer-Verlag. | * |
dc.language | English | * |
dc.title | A peptide binding to dimerized translationally controlled tumor protein modulates allergic reactions | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 89 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 603 | * |
dc.relation.lastpage | 610 | * |
dc.relation.journaltitle | Journal of Molecular Medicine | * |
dc.identifier.doi | 10.1007/s00109-011-0740-8 | * |
dc.identifier.wosid | WOS:000290817600008 | * |
dc.identifier.scopusid | 2-s2.0-79959955190 | * |
dc.author.google | Kim M. | * |
dc.author.google | Chung J. | * |
dc.author.google | Lee C. | * |
dc.author.google | Jung J. | * |
dc.author.google | Kwon Y. | * |
dc.author.google | Lee K. | * |
dc.contributor.scopusid | 이경림(7501517435) | * |
dc.contributor.scopusid | 권영주(12446435600) | * |
dc.date.modifydate | 20240301081003 | * |