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Apolipoprotein B is highly associated with the risk of coronary heart disease as estimated by the framingham risk score in healthy Korean men

Title
Apolipoprotein B is highly associated with the risk of coronary heart disease as estimated by the framingham risk score in healthy Korean men
Authors
Ryoo J.-H.Ha E.-H.Kim S.-G.Ryu S.Lee D.-W.
Ewha Authors
하은희
SCOPUS Author ID
하은희scopus
Issue Date
2011
Journal Title
Journal of Korean Medical Science
ISSN
1011-8934JCR Link
Citation
vol. 26, no. 5, pp. 631 - 636
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
The aim of this study was to examine the association between serum apolipoprotein B (apoB) and the risk of coronary heart disease (CHD) using Framingham risk score (FRS) in healthy Korean men. A total of 13,523 men without medication history of diabetes and hypertension were enrolled in this study. The FRS is based on six coronary risk factors. FRS ≥ 10% was defined as more-than-a-moderate risk group and FRS ≥ 20% as high risk group, respectively. The logistic regression analyses were conducted. When quartile 1 (Q1) set as a reference, in unadjusted analyses, the Q2, Q3, Q4 of apoB level had increased odds ratio (OR) for the risk of CHD in both more-than-a-moderate risk and high risk group, respectively. After adjusting for confounding variables, multivariable-adjusted logistic regression analyses showed a strong relationship between the quartiles of apoB level and more-than-a-moderate risk and high risk group, respectively. These associations were attenuated, but still remained statistically significant. ApoB is found to be independently related to the risk of CHD using FRS in healthy Korean men, and the link between apoB and the risk of CHD is dose-depedent. © 2011 The Korean Academy of Medical Sciences.
DOI
10.3346/jkms.2011.26.5.631
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의학전문대학원 > 의학과 > Journal papers
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