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Crowding-induced structural alterations of random-loop chromosome model

Title
Crowding-induced structural alterations of random-loop chromosome model
Authors
Kim J.S.Backman V.Szleifer I.
Ewha Authors
김준수
SCOPUS Author ID
김준수scopus
Issue Date
2011
Journal Title
Physical Review Letters
ISSN
0031-9007JCR Link
Citation
vol. 106, no. 16
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We investigate structural alterations of random-loop polymers due to changes in the crowding condition, as a model to study environmental effects on the structure of chromosome subcompartments. The polymer structure is changed in a nonmonotonic fashion with an increasing density of crowders: condensed at small volume fractions; decondensed at high crowding volume fractions. The nonmonotonic behavior is a manifestation of the nontrivial distance dependence of the depletion interactions. We also show that crowding-induced structural alterations affect the access of binding proteins to the surface of polymer segments and are distinguished from structural changes due to the increased number of specific polymer loops. © 2011 American Physical Society.
DOI
10.1103/PhysRevLett.106.168102
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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