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Impact of white matter changes on activities of daily living in mild to moderate dementia

Title
Impact of white matter changes on activities of daily living in mild to moderate dementia
Authors
Moon S.Y.Na D.L.Seo S.W.Lee J.-Y.Ku B.D.Kim S.Y.Park K.W.Shim Y.S.Youn Y.C.Chung C.-S.Cheong H.-K.Choi S.H.Cha K.R.Kim J.-E.Jeong J.H.
Ewha Authors
정지향김지은
SCOPUS Author ID
정지향scopus; 김지은scopus
Issue Date
2011
Journal Title
European Neurology
ISSN
0014-3022JCR Link
Citation
vol. 65, no. 4, pp. 223 - 230
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The association between white matter changes and activities of daily living (ADL) in a large, well-defined cohort of patients with mild-to-moderate dementia (either Alzheimer's disease or subcortical vascular dementia) were investigated. A total of 289 patients were divided into three groups (140 mild, 99 moderate, and 50 severe) depending on the degree of white matter changes as indicated on brain magnetic resonance image scans. Further, we analyzed the three groups' performances on basic and instrumental ADL. The degree of white matter changes was associated with greater age, hypertension, previous history of stroke, higher Hachinski Ischemic Score, worse global cognitive and functional status, and an increased impairment of basic ADL and instrumental ADL. The increased impairment with regard to the severe group's performance on both the basic and instrumental ADL remained significant after adjustment for age and hypertension. Tasks involving physical activities were most significant. This was the first study investigating the association between white matter changes and ADL in a large, well-defined dementia cohort. The present study suggests that severe white matter changes may be associated with higher impairment on both basic and instrumental ADL. Copyright © 2010 S. Karger AG, Basel.
DOI
10.1159/000318161
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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