Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서은경 | * |
dc.date.accessioned | 2016-08-28T12:08:36Z | - |
dc.date.available | 2016-08-28T12:08:36Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 0163-3864 | * |
dc.identifier.other | OAK-7546 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221596 | - |
dc.description.abstract | The potential antitumor activity of timosaponin A-III (1), a steroidal saponin from the rhizomes of Anemarrhena asphodeloides, was investigated in human colorectal cancer HCT-15 cells both in cell culture and in an in vivo murine xenograft model. Compound 1 inhibited the proliferation of cancer cells with cell-cycle arrest and induction of apoptosis. Cell-cycle arrest in the G0/G1 and G2/M phase by 1 was correlated with the down-regulation of cyclin A, cyclin B1, cyclin-dependent kinase 2 (CDK2), CDK4, proliferating cell nuclear antigen, and c-Myc. The increase of the sub-G1 peak by 1 was also closely related to the induction of apoptosis, which was evidenced by the induction of DNA fragmentation, activation of caspases, induction of cleaved poly-(ADP ribose) polymerase, and suppression of Bcl-xL and Bcl-2 expression. In an in vivo xenograft model, treatment with 1 (2 or 5 mg/kg body weight, three times/week, ip administration) for four weeks significantly suppressed tumor growth in athymic nude mice bearing HCT-15 cells, without any overt toxicity. Cell-cycle arrest and induction of apoptosis might be plausible mechanisms of actions for the observed antineoplastic activity of 1. © 2011 The American Chemical Society and American Society of Pharmacognosy. | * |
dc.language | English | * |
dc.title | Cytotoxic and antineoplastic activity of timosaponin A-III for human colon cancer cells | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 74 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 701 | * |
dc.relation.lastpage | 706 | * |
dc.relation.journaltitle | Journal of Natural Products | * |
dc.identifier.doi | 10.1021/np1007735 | * |
dc.identifier.wosid | WOS:000289742300025 | * |
dc.identifier.scopusid | 2-s2.0-79955412969 | * |
dc.author.google | Kang Y.-J. | * |
dc.author.google | Chung H.-J. | * |
dc.author.google | Nam J.-W. | * |
dc.author.google | Park H.J. | * |
dc.author.google | Seo E.K. | * |
dc.author.google | Kim Y.S. | * |
dc.author.google | Lee D. | * |
dc.author.google | Lee S.K. | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.date.modifydate | 20240118144717 | * |