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The 70-gene prognostic signature for korean breast cancer patients

Title
The 70-gene prognostic signature for korean breast cancer patients
Authors
Na K.Y.Kim K.S.Lee J.E.Kim H.J.Yang J.-H.Ahn S.-H.Moon B.-I.Kim R.M.Ko S.M.Jung Y.S.
Ewha Authors
문병인
SCOPUS Author ID
문병인scopus
Issue Date
2011
Journal Title
Journal of Breast Cancer
ISSN
1738-6756JCR Link
Citation
vol. 14, no. 1, pp. 33 - 38
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Purpose: A 70-gene prognostic signature has prognostic value in patients with node-negative breast cancer in Europe. This diagnostic test known as "Mamma PrintTM (70-gene prognostic signature)" was recently validated and implementation was feasible. Therefore, we assessed the 70-gene prognostic signature in Korean patients with breast cancer. We compared the risk predicted by the 70-gene prognostic signature with commonly used clinicopathological guidelines among Korean patients with breast cancer. We also analyzed the 70-gene prognostic signature and clinicopathological feature of the patients in comparison with a previous validation study. Methods: Forty-eight eligible patients with breast cancer (clinical T1-2N0M0) were selected from four hospitals in Korea. Fresh tumor samples were analyzed with a customized micro array for the 70-gene prognostic signature. Concordance between the risk predicted by the 70-gene prognostic signature and risk predicted by commonly used clinico-pathological guidelines (St. Gallen guidelines, National Institutes of Health [NIH] guideline, and Adjuvant! Online) was evaluated. Results: Prognosis signatures were assessed in 36 patients. No significant differences were observed in the clinicopathological features of patients compared with previous studies. The 70-gene prognosis signature identified five (13.9%) patients with a low-risk prognosis signature and 31 (86.1%) patients with a high-risk prognosis signature. Clinical risk was concordant with the prognosis signature for 29 patients (80.6%) according to the St. Gallen guidelines; 30 patients (83.4%) according to the NIH guidelines; and 23 patients (63.8%) according to the Adjuvant! Online. Our results were different from previous validation studies in Europe with about a 40% low-risk prognosis and about a 60% high-risk prognosis. The high incidence in the high-risk group was consistent with data in Japan. Conclusion: The results of 70-gene prognostic signature of Korean patients with breast cancer were somewhat different from those identified in Europe. This difference should be studied as whether there is a gene disparity between Asians and Europeans. Further large-scale studies with a follow-up evaluation are required to assess whether the use of the 70-gene prognostic signature can predict the prognosis of Korean patients with breast cancer. © 2011 Korean Breast Cancer Society.
DOI
10.4048/jbc.2011.14.1.33
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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