Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정병문 | * |
dc.date.accessioned | 2016-08-28T12:08:30Z | - |
dc.date.available | 2016-08-28T12:08:30Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 0024-9297 | * |
dc.identifier.other | OAK-7475 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221540 | - |
dc.description.abstract | Amphiphilic block copolymers can self-assemble into micelles in water and can further form thermosensitive gels. Here, we explored Pluronic F127 ABA triblock copolymer of poly(ethylene glycol) (PEG; A) and poly(propylene glycol) (PPG; B), modified with telechelic ionic peptides, either anionic Gly-Phe-Gly-Asp (GFGD) or zwitterionic Gly-Arg-Gly-Leu (GRGL) or Gly-Arg-Gly-Asp (GRGD). All block copolymers formed micelles, but only those bearing zwitterionic peptides formed thermoreversible nanoassembly of micellar aggregates. These aggregates facilitate to form a gel at high polymer concentrations, thus making the sol-to-gel transition temperature lower than F127 and FGM. An increase in the sol-to-gel transition temperature and a decrease in the gel modulus have been a concern for biomedical applications of hydrophobically modified Pluronics. Current zwitterionic modified Pluronic F127, on the contrary, decreased the sol-to-gel transition temperature without loss of the gel modulus. The gelation, evidenced by cryo-transmission electron microscopy images, involves radial growth of micelle aggregates, which is strikingly different from that of Pluronics driven by simple unimer-to-micelle transition. The RGD-containing copolymer is of particular interest, in that it is cytocompatible and capable of binding to cell-surface adhesion receptors. This work suggests a new platform in designing a temperature-sensitive polymer with a unique nanoassembly for tissue regeneration. © 2011 American Chemical Society. | * |
dc.language | English | * |
dc.title | Thermoreversible radial growth of micellar assembly for hydrogel formation using zwitterionic oligopeptide copolymer | * |
dc.type | Article | * |
dc.relation.issue | 7 | * |
dc.relation.volume | 44 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 2269 | * |
dc.relation.lastpage | 2275 | * |
dc.relation.journaltitle | Macromolecules | * |
dc.identifier.doi | 10.1021/ma200003b | * |
dc.identifier.wosid | WOS:000289028500070 | * |
dc.identifier.scopusid | 2-s2.0-79953896581 | * |
dc.author.google | Choi B.G. | * |
dc.author.google | Cho S.-H. | * |
dc.author.google | Lee H. | * |
dc.author.google | Cha M.H. | * |
dc.author.google | Park K. | * |
dc.author.google | Jeong B. | * |
dc.author.google | Han D.K. | * |
dc.contributor.scopusid | 정병문(7102237959) | * |
dc.date.modifydate | 20240118155902 | * |