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Syndecans as cell surface receptors: Unique structure equates with functional diversity

Title
Syndecans as cell surface receptors: Unique structure equates with functional diversity
Authors
Choi Y.Chung H.Jung H.Couchman J.R.Oh E.-S.
Ewha Authors
오억수
SCOPUS Author ID
오억수scopus
Issue Date
2011
Journal Title
Matrix Biology
ISSN
0945-053XJCR Link
Citation
vol. 30, no. 2, pp. 93 - 99
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
An increasing number of functions for syndecan cell surface heparan sulfate proteoglycans have been proposed over the last decade. Moreover, aberrant syndecan regulation has been found to play a critical role in multiple pathologies, including cancers, as well as wound healing and inflammation. As receptors, they have much in common with other molecules on the cell surface. Syndecans are type I transmembrane molecules with cytoplasmic domains that link to the actin cytoskeleton and can interact with a number of regulators. However, they are also highly complex by virtue of their external glycosaminoglycan chains, especially heparan sulfate. This heterodisperse polysaccharide has the potential to interact with many ligands from diverse protein families. Here, we relate the structural features of syndecans to some of their known functions. © 2010 International Society of Matrix Biology.
DOI
10.1016/j.matbio.2010.10.006
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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