Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유권 | * |
dc.contributor.author | 김태헌 | * |
dc.date.accessioned | 2016-08-28T12:08:30Z | - |
dc.date.available | 2016-08-28T12:08:30Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 0944-1174 | * |
dc.identifier.other | OAK-7472 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221537 | - |
dc.description.abstract | Background: This study was conducted to evaluate the durability of clevudine-induced viral response after the withdrawal of treatment. Methods: Patients who showed a complete response [alanine aminotransferase (ALT) normalization and hepatitis B virus (HBV) DNA <4,700 copies/mL for hepatitis B envelope antigen (HBeAg)-negative patients; ALT normalization, HBV DNA <4,700 copies/mL, and HBeAg seroconversion for HBeAg-positive patients] in the previous clevudine phase III trials were followed for an additional 96 weeks without any treatment for hepatitis B. Results: Of the 63 patients in the study cohort, 73% and 35% of the patients had HBV DNA <141,500 and <4,700 copies/mL, respectively, and 75% of the patients had normal ALT at the end of follow-up. HBeAg seroconversion was maintained in 81% of the patients and hepatitis B surface antigen (HBsAg) loss occurred in 3 patients. Continued HBsAg titer decrease (-0.5 log IU/mL) was observed in the sustained viral responders, suggesting the reduction of covalently closed circular DNA in hepatocytes. Conclusions: The clevudine-induced viral response was durable in the majority of patients for 2 years after the withdrawal of treatment. © 2010 Springer. | * |
dc.language | English | * |
dc.title | Clevudine-induced viral response, associated with continued reduction of HBsAg titer, was durable after the withdrawal of therapy | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 46 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 410 | * |
dc.relation.lastpage | 414 | * |
dc.relation.journaltitle | Journal of Gastroenterology | * |
dc.identifier.doi | 10.1007/s00535-010-0354-x | * |
dc.identifier.wosid | WOS:000289003700015 | * |
dc.identifier.scopusid | 2-s2.0-79954420265 | * |
dc.author.google | Lee H.-S. | * |
dc.author.google | Yoo B.C. | * |
dc.author.google | Lee K.S. | * |
dc.author.google | Kim J.H. | * |
dc.author.google | Um S.-H. | * |
dc.author.google | Ryu S.H. | * |
dc.author.google | Lee Y.-S. | * |
dc.author.google | Kim Y.S. | * |
dc.author.google | Yoo K. | * |
dc.author.google | Han J.-Y. | * |
dc.author.google | Hwang J.S. | * |
dc.author.google | Kim T.-H. | * |
dc.author.google | Yang J.-M. | * |
dc.author.google | Lee H.-J. | * |
dc.author.google | Chon C.Y. | * |
dc.author.google | Cho M. | * |
dc.author.google | Han B.H. | * |
dc.author.google | Hwang S.G. | * |
dc.author.google | Byun K.S. | * |
dc.author.google | Chung Y.-H. | * |
dc.author.google | Cho S.-H. | * |
dc.author.google | Koh K.C. | * |
dc.author.google | Kim B.-I. | * |
dc.author.google | Kim H.C. | * |
dc.author.google | Paik S.W. | * |
dc.author.google | Lee M.-S. | * |
dc.author.google | Yoo H.-W. | * |
dc.author.google | Han C.J. | * |
dc.contributor.scopusid | 유권(7202592827) | * |
dc.contributor.scopusid | 김태헌(57125156300;57219781484) | * |
dc.date.modifydate | 20240422114851 | * |