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Clevudine-induced viral response, associated with continued reduction of HBsAg titer, was durable after the withdrawal of therapy

Title
Clevudine-induced viral response, associated with continued reduction of HBsAg titer, was durable after the withdrawal of therapy
Authors
Lee H.-S.Yoo B.C.Lee K.S.Kim J.H.Um S.-H.Ryu S.H.Lee Y.-S.Kim Y.S.Yoo K.Han J.-Y.Hwang J.S.Kim T.-H.Yang J.-M.Lee H.-J.Chon C.Y.Cho M.Han B.H.Hwang S.G.Byun K.S.Chung Y.-H.Cho S.-H.Koh K.C.Kim B.-I.Kim H.C.Paik S.W.Lee M.-S.Yoo H.-W.Han C.J.
Ewha Authors
유권김태헌
SCOPUS Author ID
유권scopus; 김태헌scopus
Issue Date
2011
Journal Title
Journal of Gastroenterology
ISSN
0944-1174JCR Link
Citation
vol. 46, no. 3, pp. 410 - 414
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Background: This study was conducted to evaluate the durability of clevudine-induced viral response after the withdrawal of treatment. Methods: Patients who showed a complete response [alanine aminotransferase (ALT) normalization and hepatitis B virus (HBV) DNA <4,700 copies/mL for hepatitis B envelope antigen (HBeAg)-negative patients; ALT normalization, HBV DNA <4,700 copies/mL, and HBeAg seroconversion for HBeAg-positive patients] in the previous clevudine phase III trials were followed for an additional 96 weeks without any treatment for hepatitis B. Results: Of the 63 patients in the study cohort, 73% and 35% of the patients had HBV DNA <141,500 and <4,700 copies/mL, respectively, and 75% of the patients had normal ALT at the end of follow-up. HBeAg seroconversion was maintained in 81% of the patients and hepatitis B surface antigen (HBsAg) loss occurred in 3 patients. Continued HBsAg titer decrease (-0.5 log IU/mL) was observed in the sustained viral responders, suggesting the reduction of covalently closed circular DNA in hepatocytes. Conclusions: The clevudine-induced viral response was durable in the majority of patients for 2 years after the withdrawal of treatment. © 2010 Springer.
DOI
10.1007/s00535-010-0354-x
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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