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Clevudine-induced viral response, associated with continued reduction of HBsAg titer, was durable after the withdrawal of therapy
- Clevudine-induced viral response, associated with continued reduction of HBsAg titer, was durable after the withdrawal of therapy
- Lee H.-S.; Yoo B.C.; Lee K.S.; Kim J.H.; Um S.-H.; Ryu S.H.; Lee Y.-S.; Kim Y.S.; Yoo K.; Han J.-Y.; Hwang J.S.; Kim T.-H.; Yang J.-M.; Lee H.-J.; Chon C.Y.; Cho M.; Han B.H.; Hwang S.G.; Byun K.S.; Chung Y.-H.; Cho S.-H.; Koh K.C.; Kim B.-I.; Kim H.C.; Paik S.W.; Lee M.-S.; Yoo H.-W.; Han C.J.
- Ewha Authors
- 유권; 김태헌
- SCOPUS Author ID
- 유권; 김태헌
- Issue Date
- Journal Title
- Journal of Gastroenterology
- vol. 46, no. 3, pp. 410 - 414
- SCIE; SCOPUS
- Background: This study was conducted to evaluate the durability of clevudine-induced viral response after the withdrawal of treatment. Methods: Patients who showed a complete response [alanine aminotransferase (ALT) normalization and hepatitis B virus (HBV) DNA <4,700 copies/mL for hepatitis B envelope antigen (HBeAg)-negative patients; ALT normalization, HBV DNA <4,700 copies/mL, and HBeAg seroconversion for HBeAg-positive patients] in the previous clevudine phase III trials were followed for an additional 96 weeks without any treatment for hepatitis B. Results: Of the 63 patients in the study cohort, 73% and 35% of the patients had HBV DNA <141,500 and <4,700 copies/mL, respectively, and 75% of the patients had normal ALT at the end of follow-up. HBeAg seroconversion was maintained in 81% of the patients and hepatitis B surface antigen (HBsAg) loss occurred in 3 patients. Continued HBsAg titer decrease (-0.5 log IU/mL) was observed in the sustained viral responders, suggesting the reduction of covalently closed circular DNA in hepatocytes. Conclusions: The clevudine-induced viral response was durable in the majority of patients for 2 years after the withdrawal of treatment. © 2010 Springer.
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- 의학전문대학원 > 의학과 > Journal papers
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