View : 31 Download: 5

Predictors of pulmonary function response to treatment with salmeterol/fluticasone in patients with chronic obstructive pulmonary disease

Title
Predictors of pulmonary function response to treatment with salmeterol/fluticasone in patients with chronic obstructive pulmonary disease
Authors
Lee J.S.Huh J.W.Chae E.J.Seo J.B.Ra S.W.Lee J.-H.Kim E.-K.Lee Y.K.Kim T.-H.Kim W.J.Lee J.H.Lee S.-M.Lee S.Lim S.Y.Shin T.R.Yoon H.I.Sheen S.S.Oh Y.-M.Lee S.-D.
Ewha Authors
이진화
SCOPUS Author ID
이진화scopus
Issue Date
2011
Journal Title
Journal of Korean Medical Science
ISSN
1011-8934JCR Link
Citation
vol. 26, no. 3, pp. 379 - 385
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease and responses to therapies are highly variable. The aim of this study was to identify the predictors of pulmonary function response to 3 months of treatment with salmeterol/fluticasone in patients with COPD. A total of 127 patients with stable COPD from the Korean Obstructive Lung Disease (KOLD) Cohort, which were prospectively recruited from June 2005 to September 2009, were analyzed retrospectively. The prediction models for the FEV1, FVC and IC/TLC changes after 3 months of treatment with salmeterol/fluticasone were constructed by using multiple, stepwise, linear regression analysis. The prediction model for the FEV1 change after 3 months of treatment included wheezing history, pre-bronchodilator FEV1, post-bronchodilator FEV1 change and emphysema extent on CT (R = 0.578). The prediction models for the FVC change after 3 months of treatment included prebronchodilator FVC, post-bronchodilator FVC change (R = 0.533), and those of IC/TLC change after 3 months of treatment did pre-bronchodilator IC/TLC and post-bronchodilator FEV1 change (R = 0.401). Wheezing history, pre-bronchodilator pulmonary function, bronchodilator responsiveness, and emphysema extent may be used for predicting the pulmonary function response to 3 months of treatment with salmeterol/fluticasone in patients with COPD. © 2011 The Korean Academy of Medical Sciences.
DOI
10.3346/jkms.2011.26.3.379
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
001.pdf(501.79 kB)Download
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE