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Associations between single nucleotide polymorphisms of MMP2, VEGF, and HIF1A genes and the risk of developing colorectal cancer

Title
Associations between single nucleotide polymorphisms of MMP2, VEGF, and HIF1A genes and the risk of developing colorectal cancer
Authors
Kang M.-J.Jung S.-A.Jung J.M.Kim S.-E.Jung H.-K.Kim T.-H.Shim K.-N.Yi S.Y.Yoo K.Moon I.H.
Ewha Authors
문일환이선영유권정성애정혜경심기남김태헌김성은
SCOPUS Author ID
문일환scopus; 이선영scopus; 유권scopus; 정성애scopus; 정혜경scopus; 심기남scopus; 김태헌scopus; 김성은scopus
Issue Date
2011
Journal Title
Anticancer Research
ISSN
0250-7005JCR Link
Citation
vol. 31, no. 2, pp. 575 - 584
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The aim of this study was to investigate the association between the risk for colorectal cancer and single nucleotide polymorphisms (SNP) of matrix metalloproteinase-2 (MMP2) -1306C/T, vascular endothelial growth factor (VEGF) 936C/T and hypoxia inducible factor-1α (HIF1A) 1772C/T Patients and Methods: A total 50 colorectal cancer patients (46% women, mean age 68±11 years) were enrolled. Healthy controls without evidence of cancer history or family cancer predispositions were frequency-matched to the cases by sex and age (±5 years). Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method and the genotype distribution and risk estimate were analyzed. The correlation between the genotypes and clinicopathological parameters (Dukes stage, phenotype, location, differentiation and size) among colorectal cancer patients were investigated. Results: There was a significant association between colorectal cancer and T allele-bearing genotype distribution of HIF1A 1772C/T polymorphism (Odds ratio, OR=3.63, 95% confidence interval, CI=1.08-12.18, p=0.03 for CT and TT genotypes relative to CC genotype). In addition, when stratified by age, the association remained in patients older than 60 years old (OR=13.60, 95% CI=1.63-113.24, p=0.01). However, there was no association between the genotypes of the MMP2, VEGF and HIF1A SNP and clinicopathological parameters of colorectal cancer. Conclusion: There is a significant association between the HIF1A 1772C/T SNP and the risk of developing colorectal cancer, especially in individuals older than 60 years.
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의학전문대학원 > 의학과 > Journal papers
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