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Responses of periodontal ligament stem cells on various titanium surfaces

Title
Responses of periodontal ligament stem cells on various titanium surfaces
Authors
Heo Y.-Y.Um S.Kim S.-K.Park J.-M.Seo B.M
Ewha Authors
박지만
SCOPUS Author ID
박지만scopus
Issue Date
2011
Journal Title
Oral Diseases
ISSN
1354-523XJCR Link
Citation
vol. 17, no. 3, pp. 320 - 327
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Objective: Periodontal ligament has been reported to have adult stem cells (PDLSCs) which are responsible to regenerate the alveolar bone tissue after tooth is removed from its socket. Also PDLSCs may be the stem cells responsible for the osseointegration of titanium implants after installing the implant immediately in the fresh extracted socket. Here we tested cellular responses of PDLSCs on the various titanium surfaces to verify this notion. Materials and methods: Titanium disc were prepared for the different surface textures; smooth machined, blasted with 75 and 125μm Al 2O 3 particles, and anodized. PDLSCs were cultured on these titanium discs and tested their proliferation and gene expressions of osteocalcin, osteopontin, type I collagen, and GAPDH. Results: Proliferation of PDLSCs was higher on the rough surface blasted with 75μm Al 2O 3 particles. Osteocalcin expression was increased on the Al 2O 3 particle treated-surface regardless of its particle size. Type I collagen expression was generally decreased with time in 6days culture. Conclusions: In this experiment, it was shown that cultured PDLSCs proliferate in higher rate on the rough surface especially at the 75μm Al 2O 3 particle treated surface than other surfaces. Also, osteocalcin was highly expressed on the rough surfaces treated with 75μm and 125μm Al 2O 3 particles. © 2010 John Wiley & Sons A/S.
DOI
10.1111/j.1601-0825.2010.01728.x
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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