Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오세관 | * |
dc.date.accessioned | 2016-08-28T12:08:22Z | - |
dc.date.available | 2016-08-28T12:08:22Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 1976-9148 | * |
dc.identifier.other | OAK-7400 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221471 | - |
dc.description.abstract | Sphingosine kinase (SPHK) has a central role to control cell death and cell proliferation, which is suggested as a sphingolipid rheostat by regulating the levels between ceramide and sphingosine 1-phosphate (S1P). Therefore, physiological regulators of SPHK will be a good candidate to develop a new targeted drug. For this purpose, a series of synthetic pseudoceramides were tested by SPHK assay either cell-based or cell-free system. K10PC-5 strongly inhibited SPHK, while K6PC-5 activated SPHK in cell-free system. Specifically, K6PC-5 activated SPHK under the co-treatment with 50 μM dimethylsphingosine (DMS), a SPHK inhibitor. Collectively, we developed a simple SPHK assay system to find SPHK regulatory pseudoceramide compounds, K10PC-5 and K6PC-5 which may be useful to cancer treatment or immune regulation like FTY720, a synthetic sphingolipid mimetic compound. © 2011 The Korean Society of Applied Pharmacology. | * |
dc.language | English | * |
dc.title | Effects of synthetic pseudoceramides on sphingosine kinase activity in F9-12 cells | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 19 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 134 | * |
dc.relation.lastpage | 139 | * |
dc.relation.journaltitle | Biomolecules and Therapeutics | * |
dc.identifier.doi | 10.4062/biomolther.2011.19.1.134 | * |
dc.identifier.wosid | WOS:000288108200020 | * |
dc.identifier.scopusid | 2-s2.0-79851475454 | * |
dc.author.google | Jin Y.-X. | * |
dc.author.google | Shin K.-O. | * |
dc.author.google | Park M.-Y. | * |
dc.author.google | Lee S.-H. | * |
dc.author.google | Park B.-D. | * |
dc.author.google | Oh S. | * |
dc.author.google | Yoo H.-S. | * |
dc.author.google | Lee Y.-M. | * |
dc.contributor.scopusid | 오세관(7404103757) | * |
dc.date.modifydate | 20240118133340 | * |