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Markers in morphine- and cocaine-addicted animals

Title
Markers in morphine- and cocaine-addicted animals
Authors
Hu Z.Park K.-S.Han J.-Y.Jang C.-G.Oh S.Kim H.-C.Yang C.H.Kim E.-J.Oh K.-W.
Ewha Authors
오세관
SCOPUS Author ID
오세관scopus
Issue Date
2011
Journal Title
Biomolecules and Therapeutics
ISSN
1976-9148JCR Link
Citation
vol. 19, no. 1, pp. 45 - 51
Indexed
SCIE; SCOPUS WOS scopus
Abstract
These experiments were designed to use typical makers from behaviors and molecular basis in addicted animals of morphine and cocaine. Morphine has been widely abused with a high physical dependence liability. Morphine withdrawal activates the intracellular cAMP signaling pathway and further leads to changes in the expression of the cAMP response element binding protein (CREB), which may be important to the development and expression of morphine dependence. From these experiments, repeated morphine (10 mg/kg, twice per day for 7 days) developed physical dependence. Withdrawal signs were precipitated by naloxone and also increased the expression of the CREB. In addition, repeated exposure of cocaine (15 mg/kg) to mice develops locomotor sensitization and produced lasting behavioral sensitivity. Cocaine- and amphetamine-regulated transcript peptide (CART) peptide was up-regulated by repeated administration of cocaine in the striatum. Therefore, repeated morphine induced the development of physical dependence and increased pCREB. In addition, repeated cocaine induced locomotor sensitization and over-expressed CART peptide. In conclusion, the development of physical dependence and pCREB for morphine, and locomotor sensitization and CART peptide over-expression for cocaine would be useful markers to predict the abuse potential of opioid analgesics and pychostimulant drugs in animals, respectively. © 2011 The Korean Society of Applied Pharmacology.
DOI
10.4062/biomolther.2011.19.1.045
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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