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Association of maternal folate nutrition and serum C-reactive protein concentrations with gestational age at delivery

Title
Association of maternal folate nutrition and serum C-reactive protein concentrations with gestational age at delivery
Authors
Kim H.Hwang J.-Y.Ha E.-H.Park H.Ha M.Lee S.-J.Hong Y.-C.Chang N.
Ewha Authors
하은희장남수박혜숙
SCOPUS Author ID
하은희scopus; 장남수scopus; 박혜숙scopus
Issue Date
2011
Journal Title
European Journal of Clinical Nutrition
ISSN
0954-3007JCR Link
Citation
vol. 65, no. 3, pp. 350 - 356
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Background/objectives:C-reactive protein (CRP) is the most extensively studied inflammatory risk marker, and elevated serum CRP concentrations in pregnant women are known to be associated with subsequent development of preeclampsia and preterm delivery. Researchers have suggested that folate intake may help to control the inflammation process. We examined whether folate nutrition modifies the relationship between serum CRP concentration and gestational age at delivery.Subjects/methods:Serum CRP concentrations were analyzed in 815 pregnant women between 12 and 28 weeks of gestation. Dietary intakes were assessed using a 24-h dietary recall. The serum folate and high-sensitivity CRP concentrations were analyzed by radioassay and latex agglutination tests, respectively.Results:Serum CRP concentration was negatively correlated (P<0.001) with gestational age at delivery. Serum folate concentration was negatively correlated (P<0.01) with serum CRP concentration, and total dietary folate intake was positively correlated (P<0.001) with serum folate concentration. Multiple regression analysis after adjustment for covariates revealed that maternal CRP concentrations were negatively associated with gestational age at delivery; these negative associations existed only when folate intake during pregnancy was below the Korean estimated average requirements (520 μg dietary folate equivalent per day), and serum folate concentrations were above the normal (6 ng/ml).Conclusions:We found that adequate maternal folate intake during pregnancy may have a beneficial role against shorter gestational age at delivery, which is associated with higher serum CRP concentrations in pregnant women. © 2011 Macmillan Publishers Limited. All rights reserved.
DOI
10.1038/ejcn.2010.267
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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