View : 12 Download: 0

Stimulation of renin secretion by catecholamines is dependent on adenylyl cyclases 5 and 6

Title
Stimulation of renin secretion by catecholamines is dependent on adenylyl cyclases 5 and 6
Authors
Aldehni F.Tang T.Madsen K.Plattner M.Schreiber A.Friis U.G.Hammond H.K.Han P.L.Schweda F.
Ewha Authors
한평림
SCOPUS Author ID
한평림scopus
Issue Date
2011
Journal Title
Hypertension
ISSN
0194-911XJCR Link
Citation
vol. 57, no. 3, pp. 460 - 468
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The sympathetic nervous system stimulates renin release from juxtaglomerular cells via the β-adrenoreceptor-cAMP pathway. Recent in vitro studies have suggested that the calcium-inhibited adenylyl cyclases (ACs) 5 and 6 possess key roles in the control of renin exocytosis. To investigate the relative contribution of AC5 and AC6 to the regulation of renin release in vivo we performed experiments using AC5 and AC6 knockout mice. Male AC5 mice exhibited normal plasma renin concentrations, renal renin synthesis (mRNA and renin content), urinary volume, and systolic blood pressure. In male AC6 mice, plasma renin concentration (AC6: 732±119; AC6 : 436±78 ng of angiotensin I per hour*mL; P<0.05), and renin synthesis were stimulated associated with an increased excretion of dilute urine (1.55-fold; P<0.05) and reduced blood pressure (-10.6 mm Hg; P<0.001). Stimulation of plasma renin concentration by a single injection of the β-adrenoreceptor agonist isoproterenol (10 mg/kg IP) was significantly attenuated in AC5 (male: -20%; female: -33%) compared with wild-type mice in vivo. The mitigation of the plasma renin concentration response to isoproterenol was even more pronounced in AC6 (male: -63%; female: -50% versus AC6). Similarly, the effects of isoproterenol, prostaglandin E2, and pituitary adenylyl cyclase-activating polypeptide on renin release from isolated perfused kidneys were attenuated to a higher extent in AC6 (-51% to -98% versus AC6) than in AC5 (-31% to 46% versus AC5). In conclusion, both AC5 and AC6 are involved in the stimulation of renin secretion in vivo, and AC6 is the dominant isoforms in this process. © 2011 American Heart Association, Inc.
DOI
10.1161/HYPERTENSIONAHA.110.167130
Appears in Collections:
일반대학원 > 뇌·인지과학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE