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Effect of different forms of anionic nanoclays on cytotoxicity

Title
Effect of different forms of anionic nanoclays on cytotoxicity
Authors
Baek M.Kim I.-S.Yu J.Chung H.E.Choy J.-H.Choi S.-J.
Ewha Authors
최진호
SCOPUS Author ID
최진호scopus
Issue Date
2011
Journal Title
Journal of Nanoscience and Nanotechnology
ISSN
1533-4880JCR Link
Citation
vol. 11, no. 2, pp. 1803 - 1806
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Anionic nanoclays, so-called layered double hydroxide (LDH) nanoparticles, have been extensively applied as drug delivery systems, since they efficiently enter cells via endocytosis pathway and possess controlled release property. However, the stability of LDHs varies, depending on the type of interlayer anions, which can also affect their toxicity. In this study, we investigated the effects of two different forms of LDH, carbonate form (MgAl-LDH-CO 3) and chloride form (MgAl-LDH-Cl), on cytotoxicity in human lung epithelial cells. The result showed that MgAl-LDH-Cl was more easily dissolved into metal ions under simulated lysosomal (pH 4.5) and body fluid (pH 7.4) conditions than did MgAl-LDH-CO 3. According to cytotoxicity evaluation, MgAl-LDH-CO 3 exhibited high toxicity compared with MgAl-LDH-Cl in terms of induction of oxidative stress, apoptosis and membrane damage. These results suggest that easily dissoluble MgAl-LDH-Cl has low cytotoxicity, while high Copyright © 2011 American Scientific Publishers All rights reserved stability of MgAl-LDH-CO 3 is correlated to elevated cytotoxicity. Copyright © 2011 American Scientific Publishers All rights reserved.
DOI
10.1166/jnn.2011.3408
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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