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Clinical outcomes and prognostic factors in patients with tuberculous destroyed lung

Title
Clinical outcomes and prognostic factors in patients with tuberculous destroyed lung
Authors
Ryu Y.J.Lee J.H.Chun E-M.Chang J.H.Shim S.S.
Ewha Authors
장중현이진화천은미심성신류연주
SCOPUS Author ID
장중현scopus; 이진화scopus; 천은미scopus; 심성신scopus; 류연주scopus
Issue Date
2011
Journal Title
International Journal of Tuberculosis and Lung Disease
ISSN
1027-3719JCR Link
Citation
vol. 15, no. 2, pp. 246 - 250
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
OBJECTIVE: To characterise the prognosis and identify factors contributing to mortality in patients with tuberculous destroyed lung (TDL).DESIGN: Following a retrospective review of clinical data and radiographic fi ndings, 169 patients with TDL were enrolled in this study.All patients were graded on a 4-point scale (fi eld score 1-4) based on the extent of destroyed lung parenchyma on chest radiography.RESULTS: The mean patient age was 64 years (range 33- 90); 103 (61%) were male.The median number of hospitalizations was 1 (range 0-11) during follow-up, with a mean duration of 31 months (range 0-172).Pneumonia developed in 96 patients (57%), while 50 patients (30%) developed acute respiratory failure requiring mechanical ventilation, 37 (22%) haemoptysis, 24 (14%) spontaneous pneumothorax and 22 (13%) reactivation of tuberculosis.Overall mortality was 28% (47/169), with a median survival of 39 months (range 0-176) after diagnosis.TDL-related mortality was 19% (32/169),and a fi eld score ?3 was the only independent predictor of shorter survival based on a Cox proportional hazards model (HR 3.520, 95%CI 1.51-8.20, P = 0.004).CONCLUSION: TDL has a poor prognosis, particularly in patients with more extensive lung destruction. © 2011 The Union.
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의학전문대학원 > 의학과 > Journal papers
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