Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이향운 | * |
dc.date.accessioned | 2016-08-28T12:08:10Z | - |
dc.date.available | 2016-08-28T12:08:10Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 1059-1311 | * |
dc.identifier.other | OAK-7280 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221361 | - |
dc.description.abstract | Purpose: In this prospective study, we compared the long-term cognitive and behavioral effects of lamotrigine (LTG) and carbamazepine (CBZ) in patients with newly diagnosed or untreated partial epilepsy. Methods: This was a multicenter, open-label, randomized study that compared monotherapy with LTG and CBZ in newly diagnosed or untreated patients with partial epilepsy. We employed an 8-week titration period and a 40-week maintenance period. Neuropsychological tests, Symptom Check List-90, and QOLIE-31 were assessed at baseline, 16 weeks, and 48 weeks after drug treatment. A group-by-time interaction was the primary outcome measure and was analyzed by use of the linear mixed model. Results: A total of 110 patients were eligible and 73 completed the 48-week study (LTG, n = 39; CBZ, n = 34). Among the cognitive tests, significant group-by-time interaction was identified only in phonemic fluency of Controlled Oral Word Association Task (p = 0.0032) and Stroop Color-Word Interference (p = 0.0283), with a significant better performance for LTG group. All other neuropsychological tests included did not show significant group-by-time interactions. Among the subscales of Symptom Check List-90, significant group-by-time interactions were identified in Obsessive-Compulsive (p = 0.0005), Paranoid Ideation (p = 0.0454), Global Severity Index (p = 0.0194), and Positive Symptom Total (p = 0.0197), with a significant improvement for CBZ group. QOLIE-31 did not show significant group-by-time interactions. Conclusion: Our data suggest that epilepsy patients on LTG have better performance on phonemic fluency and the task of Stroop Color-Word Interference than do patients on CBZ, whereas patients on CBZ had more favorable behavioral effects on two subscales and two global scores of Symptom Check List-90 than did patients on LTG. © 2010 British Epilepsy Association. | * |
dc.language | English | * |
dc.title | Cognitive and behavioral effects of lamotrigine and carbamazepine monotherapy in patients with newly diagnosed or untreated partial epilepsy | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 20 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 49 | * |
dc.relation.lastpage | 54 | * |
dc.relation.journaltitle | Seizure | * |
dc.identifier.doi | 10.1016/j.seizure.2010.10.006 | * |
dc.identifier.wosid | WOS:000286866100009 | * |
dc.identifier.scopusid | 2-s2.0-78650823193 | * |
dc.author.google | Lee S.-A. | * |
dc.author.google | Lee H.-W. | * |
dc.author.google | Heo K. | * |
dc.author.google | Shin D.-J. | * |
dc.author.google | Song H.-K. | * |
dc.author.google | Kim O.-J. | * |
dc.author.google | Lee S.-M. | * |
dc.author.google | Kim S.-O. | * |
dc.author.google | Lee B.-I. | * |
dc.contributor.scopusid | 이향운(34667959700) | * |
dc.date.modifydate | 20240123091326 | * |