Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오세관 | * |
dc.contributor.author | 정재철 | * |
dc.date.accessioned | 2016-08-28T12:08:10Z | - |
dc.date.available | 2016-08-28T12:08:10Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 1344-9702 | * |
dc.identifier.other | OAK-7278 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221359 | - |
dc.description.abstract | One of the principal regulators of mitogene- sis in vascular smooth muscle cells (VSMCs) is platelet-derived growth factor-BB (PDGF-BB). An increase of PDGF-BB expression has been observed in atherosclerotic lesions. The aim of this study was to elucidate the effects and molecular mechanism of (2E)-3-(4-hydroxy-3-methoxyphenyl)phenylpro-2- en-1-one (KTJ2242), a newly synthesized benzylide- neacetophenone derivative, on PDGF-BB-stimulated rat aortic VSMCs. KTJ2242 induced accumula- tion of cells in the G1 phase of the cell cycle of VSMCs. We observed that KTJ2242 inhibited PDGF- BB-stimulated [ 3H]-thymidine incorporation into the DNA of VSMCs, and the cell number was signifi- cantly reduced in a concentration-dependent manner. Also, we observed that KTJ2242 decreased PDGF- BB-stimulated extracellular-regulated kinase 1 and 2 (ERK1/2) and Akt phosphorylation. These results suggest the possibility that KTJ2242 may be a po- tential agent with which to control vascular disorders and its antiproliferative mechanism may be mediated through partial Akt and ERK1/2-dependent signaling pathways. © 2011 The Pharmaceutical Society of Japan. | * |
dc.language | English | * |
dc.title | Potent inhibition of platelet-derived growth factor-stimulated rat aortic vascular smooth muscle cell cycle and proliferation by (2E)-3-(4-hydroxy-3-methoxyphenyl) phenylpro-2- en-1-one, a newly synthesized benzylideneacetophenone derivative | * |
dc.type | Letter | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 57 | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 86 | * |
dc.relation.lastpage | 92 | * |
dc.relation.journaltitle | Journal of Health Science | * |
dc.identifier.doi | 10.1248/jhs.57.86 | * |
dc.identifier.wosid | WOS:000286853800012 | * |
dc.identifier.scopusid | 2-s2.0-79952600599 | * |
dc.author.google | Kim T.-J. | * |
dc.author.google | Han H.-J. | * |
dc.author.google | Jung J.-C. | * |
dc.author.google | Oh S. | * |
dc.author.google | Yun Y.-P. | * |
dc.contributor.scopusid | 오세관(7404103757) | * |
dc.contributor.scopusid | 정재철(7402897187) | * |
dc.date.modifydate | 20240123112233 | * |