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Filaggrin knockdown and Toll-like receptor 3 (TLR3) stimulation enhanced the production of thymic stromal lymphopoietin (TSLP) from epidermal layers

Title
Filaggrin knockdown and Toll-like receptor 3 (TLR3) stimulation enhanced the production of thymic stromal lymphopoietin (TSLP) from epidermal layers
Authors
Lee K.H.Cho K.-A.Kim J.-Y.Baek J.-H.Woo S.-Y.Kim J.-W.
Ewha Authors
우소연조경아
SCOPUS Author ID
우소연scopus; 조경아scopus
Issue Date
2011
Journal Title
Experimental Dermatology
ISSN
0906-6705JCR Link
Citation
vol. 20, no. 2, pp. 149 - 151
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Keratinocytes constitute the first-line barrier against exogenous antigens and contain Toll-like receptors (TLRs), which function as pattern-recognition molecules to activate antimicrobial innate immune responses. In an effort to ascertain whether or not filaggrin (filament-aggregating protein) expression affected the TLR-mediated responses of keratinocytes, we transfected filaggrin siRNA into HaCaT human keratinocyte cells and determined that thymic stromal lymphopoietin (TSLP) and IL-6 secretion were increased by poly(I:C) stimulus. Additionally, TSLP expression is increased in filaggrin knockdown as well as TLR3 stimulation in reconstituted human epidermal layers. Therefore, the findings of this study show that reduced filaggrin levels may influence innate immune responses via TLR stimuli and may contribute to the pathogenesis of inflammatory skin disease via TSLP expression. © 2011 John Wiley & Sons A/S.
DOI
10.1111/j.1600-0625.2010.01203.x
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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