Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 한평림 | - |
dc.date.accessioned | 2016-08-28T12:08:04Z | - |
dc.date.available | 2016-08-28T12:08:04Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0026-895X | - |
dc.identifier.other | OAK-7230 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221314 | - |
dc.description.abstract | Cerebral ischemia leads to brain injury via a complex series of pathophysiological events. Therefore, multidrug treatments or multitargeting drug treatments are attractive options in efficiently limiting brain damage. Here, we report a novel multifunctional compound oxopropanoyloxy benzoic acid (OBA-09), a simple ester of pyruvate and salicylic acid. This protective effect was manifested by recoveries from neurological and behavioral deficits. OBA-09 exhibited antioxidative effects in the postischemic brain, which was evidenced by remarkable reduction of lipid peroxidation and 4-hydroxy-2-nonenal staining in OBA-09-administered animals. Reactive oxygen species generation was markedly suppressed in primary cortical cultures under oxygen-glucose deprivation. More interestingly, OBA-09 was capable of scavenging hydroxyl radical in cell-free assays. High-performance liquid chromatography results demonstrated that OBA-09 was hydrolyzed to salicylic acid and pyruvate with t1/2 = 43 min in serum and 4.2 h in brain parenchyma, indicating that antioxidative function of OBA-09 is executed by itself and also by salicylic acid after the hydrolysis. In addition to antioxidative function, OBA-09 exerts anti-excitotoxic and anti-Zn2+-toxic functions, which might be attributed to attenuation of ATP and nicotinamide adenine dinucleotide depletion and to the suppression of nuclear factor-κB activity induction. Together these results indicate that OBA-09 has a potent therapeutic potential as a multimodal neuroprotectant in the postischemic brain and these effects were conferred by OBA-09 itself and subsequently its hydrolyzed products. Copyright © 2011 The American Society for Pharmacology and Experimental Therapeutics Mol Pharmacol. | - |
dc.language | English | - |
dc.title | Robust protective effects of a novel multimodal neuroprotectant oxopropanoyloxy benzoic acid (a salicylic acid/pyruvate ester) in the postischemic brain | - |
dc.type | Article | - |
dc.relation.issue | 2 | - |
dc.relation.volume | 79 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 220 | - |
dc.relation.lastpage | 228 | - |
dc.relation.journaltitle | Molecular Pharmacology | - |
dc.identifier.doi | 10.1124/mol.110.067520 | - |
dc.identifier.wosid | WOS:000286311800002 | - |
dc.identifier.scopusid | 2-s2.0-78751487447 | - |
dc.author.google | Kim S.-W. | - |
dc.author.google | Kim H.J. | - |
dc.author.google | Shin J.-H. | - |
dc.author.google | Kim I.-D. | - |
dc.author.google | Lee J.-E. | - |
dc.author.google | Han P.-L. | - |
dc.author.google | Yoon S.-H. | - |
dc.author.google | Lee J.-K. | - |
dc.contributor.scopusid | 한평림(7201947605) | - |
dc.date.modifydate | 20230901081001 | - |