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Amphiphilic cyclotriphosphazenes grafted with branched oligopeptides

Title
Amphiphilic cyclotriphosphazenes grafted with branched oligopeptides
Authors
Jadhav V.B.Toti U.S.Cui J.X.Jun Y.J.Sohn Y.S.
Ewha Authors
손연수전용주
SCOPUS Author ID
손연수scopus
Issue Date
2010
Journal Title
Bulletin of the Korean Chemical Society
ISSN
0253-2964JCR Link
Citation
vol. 31, no. 12, pp. 3735 - 3739
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Branched oligopeptides prepared by coupling a very hydrophobic aspartic diamino acid ethyl ester such as Asp (LeuEt) 2, Asp(IleEt) 2 and Asp(PheEt) 2 to glycine or glycylphenylalanine were grafted to the cyclotriphosphazene backbone bearing an equimolar hydrophilic poly(ethylene glycol) (PEG). The properties of the resultant amphiphiles were examined in comparison with those of the linear oligopeptide analogues previously reported. All cyclic phosphazene trimers grafted with the branched tetra- and pentapeptides displayed a normal trend of thermosensitivity depending on their hydrophilic to hydrophobic balance, but the stability and particle size of their micelles were found to be greatly dependent on the fine structure of the branched oligopeptides grafted. The trimers bearing branched tetrapeptides with a low hydrophobicity were found to form unstable micelles initially, which reassemble into thermodynamically more stable polymersomes.
DOI
10.5012/bkcs.2010.31.12.3735
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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