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FISH-negative cryptic PML-RARA rearrangement detected by long-distance polymerase chain reaction and sequencing analyses: A case study and review of the literature

Title
FISH-negative cryptic PML-RARA rearrangement detected by long-distance polymerase chain reaction and sequencing analyses: A case study and review of the literature
Authors
Kim M.J.Cho S.Y.Kim M.-H.Lee J.J.Kang S.Y.Cho E.H.Huh J.Yoon H.-J.Park T.S.Lee W.-I.Marschalek R.Meyer C.
Ewha Authors
허정원
SCOPUS Author ID
허정원scopus
Issue Date
2010
Journal Title
Cancer Genetics and Cytogenetics
ISSN
0165-4608JCR Link
Citation
vol. 203, no. 2, pp. 278 - 283
Indexed
SCOPUS WOS scopus
Abstract
Although a normal karyotype according to conventional cytogenetic analysis in association with cryptic t(15;17) has been infrequently reported in cases of acute promyelocytic leukemia (APL), a fluorescence in situ hybridization (FISH)-negative cryptic PML-RARA rearrangement is even more rare, with only 12 such APL cases of FISH-negative cryptic PML-RARA rearrangements in the literature. Reported here is an additional clinical APL case with a FISH-negative cryptic PML-RARA rearrangement, confirmed by long-distance DNA polymerase chain reaction method. Discussion includes a relevant literature review of similar cases. DNA-PCR can be a useful tool for the analysis of complex and cryptic rearrangements. © 2010 Elsevier Inc.
DOI
10.1016/j.cancergencyto.2010.08.026
Appears in Collections:
의과대학 > 의학과 > Journal papers
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