Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김승철 | - |
dc.date.accessioned | 2016-08-28T12:08:57Z | - |
dc.date.available | 2016-08-28T12:08:57Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1048-891X | - |
dc.identifier.other | OAK-7172 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221261 | - |
dc.description.abstract | Background: Human papillomavirus can stabilize and induce hypoxia-inducible factor 1α (HIF-1α) protein, which is associated with diminished response to treatment and poor prognosis for cervical cancer. Hypoxia-inducible factor 1α polymorphisms (1772C > T and 1790G > A) in the N-terminal transactivation domain generate significantly increased transcriptional activity and have been linked to poor outcome in various malignancies. Objective: The aim of this study was to analyze the possible influence of HIF-1α genetic polymorphisms on cancer susceptibility, tumor aggressiveness, and survival of patients with early-stage cervical cancer. Methods: One hundred ninety-nine patients with early-stage cervical cancer who were treated with surgical resection were retrospectively investigated. Hypoxia-inducible factor 1α 1772C > T and 1790G > A genetic polymorphisms were compared with 205 healthy subjects and correlated with the clinical outcome of patients with early-stage cervical cancer. Results: The risk of cervical cancer was not affected by HIF-1α 1772C > T and 1790G > A polymorphisms. However, lymph node metastasis was significantly increased in patients who had the 1790 variant (adjusted odds ratio, 5.01; 95% confidence interval, 1.05Y23.88; P = 0.043). In survival analysis, HIF-1α 1772C > T and 1790G > A polymorphisms were not related to disease-free survival and overall survival. Conclusions: Although HIF-1α genetic polymorphisms had little association with cervical cancer risk and prognosis, individual variance of HIF-1α gene may be associated with cervical cancer invasiveness. Copyright © 2010 by IGCS and ESGO. | - |
dc.language | English | - |
dc.title | Hypoxia-inducible factor 1α polymorphisms and early-stage cervical cancer | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 21 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 2 | - |
dc.relation.lastpage | 7 | - |
dc.relation.journaltitle | International Journal of Gynecological Cancer | - |
dc.identifier.doi | 10.1097/IGC.0b013e318204f6e6 | - |
dc.identifier.wosid | WOS:000285582500002 | - |
dc.identifier.scopusid | 2-s2.0-79951472952 | - |
dc.author.google | Kim Y.H. | - |
dc.author.google | Park I.A. | - |
dc.author.google | Park W.-Y. | - |
dc.author.google | Kim J.W. | - |
dc.author.google | Kim S.C. | - |
dc.author.google | Park N.-H. | - |
dc.author.google | Song Y.-S. | - |
dc.author.google | Kang S.-B. | - |
dc.contributor.scopusid | 김승철(35264000100) | - |
dc.date.modifydate | 20230210135401 | - |