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dc.contributor.author김승철-
dc.date.accessioned2016-08-28T12:08:57Z-
dc.date.available2016-08-28T12:08:57Z-
dc.date.issued2011-
dc.identifier.issn1048-891X-
dc.identifier.otherOAK-7172-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/221261-
dc.description.abstractBackground: Human papillomavirus can stabilize and induce hypoxia-inducible factor 1α (HIF-1α) protein, which is associated with diminished response to treatment and poor prognosis for cervical cancer. Hypoxia-inducible factor 1α polymorphisms (1772C > T and 1790G > A) in the N-terminal transactivation domain generate significantly increased transcriptional activity and have been linked to poor outcome in various malignancies. Objective: The aim of this study was to analyze the possible influence of HIF-1α genetic polymorphisms on cancer susceptibility, tumor aggressiveness, and survival of patients with early-stage cervical cancer. Methods: One hundred ninety-nine patients with early-stage cervical cancer who were treated with surgical resection were retrospectively investigated. Hypoxia-inducible factor 1α 1772C > T and 1790G > A genetic polymorphisms were compared with 205 healthy subjects and correlated with the clinical outcome of patients with early-stage cervical cancer. Results: The risk of cervical cancer was not affected by HIF-1α 1772C > T and 1790G > A polymorphisms. However, lymph node metastasis was significantly increased in patients who had the 1790 variant (adjusted odds ratio, 5.01; 95% confidence interval, 1.05Y23.88; P = 0.043). In survival analysis, HIF-1α 1772C > T and 1790G > A polymorphisms were not related to disease-free survival and overall survival. Conclusions: Although HIF-1α genetic polymorphisms had little association with cervical cancer risk and prognosis, individual variance of HIF-1α gene may be associated with cervical cancer invasiveness. Copyright © 2010 by IGCS and ESGO.-
dc.languageEnglish-
dc.titleHypoxia-inducible factor 1α polymorphisms and early-stage cervical cancer-
dc.typeArticle-
dc.relation.issue1-
dc.relation.volume21-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage2-
dc.relation.lastpage7-
dc.relation.journaltitleInternational Journal of Gynecological Cancer-
dc.identifier.doi10.1097/IGC.0b013e318204f6e6-
dc.identifier.wosidWOS:000285582500002-
dc.identifier.scopusid2-s2.0-79951472952-
dc.author.googleKim Y.H.-
dc.author.googlePark I.A.-
dc.author.googlePark W.-Y.-
dc.author.googleKim J.W.-
dc.author.googleKim S.C.-
dc.author.googlePark N.-H.-
dc.author.googleSong Y.-S.-
dc.author.googleKang S.-B.-
dc.contributor.scopusid김승철(35264000100)-
dc.date.modifydate20180329110405-
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의과대학 > 의학과 > Journal papers
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