Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정화순 | * |
dc.contributor.author | 성주명 | * |
dc.contributor.author | 허정원 | * |
dc.contributor.author | 문영철 | * |
dc.date.accessioned | 2016-08-28T12:08:56Z | - |
dc.date.available | 2016-08-28T12:08:56Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 1598-6535 | * |
dc.identifier.other | OAK-7164 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221254 | - |
dc.description.abstract | A variant Philadelphia chromosome (Ph) is generated from translocation of one or more partner chromosomes in addition to chromosomes 9 and 22. We have described the cases of 2 patients bearing variant Ph detected by interphase FISH but not detected by G-banded karyotyping and metaphase FISH. FISH was performed using BCR/ABL dual color dual fusion translocation probes (Abbott Molecular, USA). A 52-year-old man was diagnosed with acute leukemia of mixed phenotype. G-banded karyotyping showed 46, XY, t(9; 22)(q34; q11.2)[12]/47, idem,+der(22)t(9; 22)[5]/46, XY[3]. Interphase FISH revealed nuc ish(ABL1, BCR) × 3(ABL1 con BCR × 2)[329/450]/(ABL1, BCR) × 4(ABL1 con BCR × 3)[5/450]/(AL1, BCR) × 3(ABL1 con BCR × 1)[44/450]. Metaphase FISH showed ish (9; 22)(ABL1+, BCR1+; BCR+, ABL+)[22]/der(22)(BCR+, ABL1+)[3]. The other case was that of a 31-yr-old male patient diagnosed with CML in the blastic phase. G-banded karyotyping of all 20 metaphase cells showed 47, XYYc, dup(1)(q21q32), del(7)(p11.2), t(9; 22)(q34; q11.2). Interphase FISH revealed nuc ish(ABL1, BCR) × 3(ABL1 con BCR × 2)[254/600]/(ABL1, BCR) × 3(ABL1 con BCR × 1)[191/600]. Metaphase FISH showed ish t(9; 22)(ABL1+, BCR+; BCR+, ABL1+)[16]. These results suggest that typical t(9; 22) and variant Ph may coexist in the same patient, and interphase FISH may facilitate the detection of the variant Ph that cannot be detected by G-banded karyotyping alone. © The Korean Society for Laboratory Medicine. | * |
dc.language | Korean | * |
dc.title | Variant Philadelphia chromosome identified by interphase fluorescence in situ hybridization (FISH) without evidence on G-banded karyotyping and metaphase FISH | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 30 | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 711 | * |
dc.relation.lastpage | 717 | * |
dc.relation.journaltitle | Korean Journal of Laboratory Medicine | * |
dc.identifier.doi | 10.3343/kjlm.2010.30.6.711 | * |
dc.identifier.wosid | WOS:000285530300027 | * |
dc.identifier.scopusid | 2-s2.0-78651336736 | * |
dc.author.google | Kim M.K. | * |
dc.author.google | Mun Y.C. | * |
dc.author.google | Seong C.M. | * |
dc.author.google | Chung W.S. | * |
dc.author.google | Huh J. | * |
dc.contributor.scopusid | 정화순(7401983201;54885771500) | * |
dc.contributor.scopusid | 성주명(7005537065) | * |
dc.contributor.scopusid | 허정원(7102258576) | * |
dc.contributor.scopusid | 문영철(7003363716) | * |
dc.date.modifydate | 20240422115947 | * |