Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 정환 | - |
dc.date.accessioned | 2016-08-28T12:08:59Z | - |
dc.date.available | 2016-08-28T12:08:59Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0165-0378 | - |
dc.identifier.other | OAK-7131 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221236 | - |
dc.description.abstract | Recent findings suggest that the association between inflammation-related genes and preterm delivery may be stronger in the presence of bacterial vaginosis (BV). Tumor necrosis factor-alpha (TNFα) and interleukin 1-beta (IL-1β) are pro-inflammatory cytokines capable of inducing preterm labor in non-human primates. In this study the authors tested associations among two TNFα promoter polymorphisms (-G308A and -G238A), a single IL-1β polymorphism (+C3954T), vaginal microbial findings, and risk of preterm delivery. Data were from the Pregnancy Outcomes and Community Health (POUCH) Study (n= 777 term and n= 230 preterm deliveries). Vaginal smears collected at mid-pregnancy (15-27 weeks gestation) were scored according to Nugent's criteria. A Nugent score of ≥4 was modeled as the cut-point for intermediate and positive BV. Logistic regression was used to estimate odds ratios for associations among independent covariates (vaginal flora, genotype) and preterm delivery. Results showed that women with a Nugent score of ≥ 4 and the TNFα -238 A/G or A/A were at increased risk of delivering preterm (race/ethnicity adjusted OR 2.6, 95% CI 1.2, 5.8). The p-value for the genotype and Nugent score interaction. = 0.02. This study points to one more example of a potential gene-environment interaction in a preterm delivery pathway. Future tests of this finding will determine the robustness of these results. © 2010 Elsevier Ireland Ltd. | - |
dc.language | English | - |
dc.title | Interplay of cytokine polymorphisms and bacterial vaginosis in the etiology of preterm delivery | - |
dc.type | Article | - |
dc.relation.issue | 41276 | - |
dc.relation.volume | 87 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 82 | - |
dc.relation.lastpage | 89 | - |
dc.relation.journaltitle | Journal of Reproductive Immunology | - |
dc.identifier.doi | 10.1016/j.jri.2010.06.158 | - |
dc.identifier.wosid | WOS:000285320400011 | - |
dc.identifier.scopusid | 2-s2.0-78449281638 | - |
dc.author.google | Jones N.M. | - |
dc.author.google | Holzman C. | - |
dc.author.google | Friderici K.H. | - |
dc.author.google | Jernigan K. | - |
dc.author.google | Chung H. | - |
dc.author.google | Fisher R. | - |
dc.author.google | Wirth J. | - |
dc.contributor.scopusid | 정환(7404006411) | - |
dc.date.modifydate | 20211210153830 | - |