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dc.contributor.author정환-
dc.date.accessioned2016-08-28T12:08:59Z-
dc.date.available2016-08-28T12:08:59Z-
dc.date.issued2010-
dc.identifier.issn0165-0378-
dc.identifier.otherOAK-7131-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/221236-
dc.description.abstractRecent findings suggest that the association between inflammation-related genes and preterm delivery may be stronger in the presence of bacterial vaginosis (BV). Tumor necrosis factor-alpha (TNFα) and interleukin 1-beta (IL-1β) are pro-inflammatory cytokines capable of inducing preterm labor in non-human primates. In this study the authors tested associations among two TNFα promoter polymorphisms (-G308A and -G238A), a single IL-1β polymorphism (+C3954T), vaginal microbial findings, and risk of preterm delivery. Data were from the Pregnancy Outcomes and Community Health (POUCH) Study (n= 777 term and n= 230 preterm deliveries). Vaginal smears collected at mid-pregnancy (15-27 weeks gestation) were scored according to Nugent's criteria. A Nugent score of ≥4 was modeled as the cut-point for intermediate and positive BV. Logistic regression was used to estimate odds ratios for associations among independent covariates (vaginal flora, genotype) and preterm delivery. Results showed that women with a Nugent score of ≥ 4 and the TNFα -238 A/G or A/A were at increased risk of delivering preterm (race/ethnicity adjusted OR 2.6, 95% CI 1.2, 5.8). The p-value for the genotype and Nugent score interaction. = 0.02. This study points to one more example of a potential gene-environment interaction in a preterm delivery pathway. Future tests of this finding will determine the robustness of these results. © 2010 Elsevier Ireland Ltd.-
dc.languageEnglish-
dc.titleInterplay of cytokine polymorphisms and bacterial vaginosis in the etiology of preterm delivery-
dc.typeArticle-
dc.relation.issue41276-
dc.relation.volume87-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage82-
dc.relation.lastpage89-
dc.relation.journaltitleJournal of Reproductive Immunology-
dc.identifier.doi10.1016/j.jri.2010.06.158-
dc.identifier.wosidWOS:000285320400011-
dc.identifier.scopusid2-s2.0-78449281638-
dc.author.googleJones N.M.-
dc.author.googleHolzman C.-
dc.author.googleFriderici K.H.-
dc.author.googleJernigan K.-
dc.author.googleChung H.-
dc.author.googleFisher R.-
dc.author.googleWirth J.-
dc.contributor.scopusid정환(7404006411)-
dc.date.modifydate20211210153830-
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자연과학대학 > 통계학전공 > Journal papers
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