Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 정익모 | * |
dc.date.accessioned | 2016-08-28T12:08:58Z | - |
dc.date.available | 2016-08-28T12:08:58Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 0167-5273 | * |
dc.identifier.other | OAK-7118 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221224 | - |
dc.description.abstract | Background: Extracellular matrix (ECM) accumulation significantly contributes to in-stent restenosis. In this regard, transforming growth factor (TGF)-β, a positive regulator of ECM deposition, may be implicated in in-stent restenosis. The goal of this study was to assess the effect of blockade of TGF-β on stent-induced restenosis in porcine coronary arteries. Methods: An adenovirus expressing the ectodomain of the TGF-β type II receptor (AdTβ-ExR) was applied onto a coronary arterial segment of a pig (n = 10) using an Infiltrator TM, followed by stent deployment. Controls consisted of adenoviruses expressing β-galactosidase (AdLacZ) or phosphate-buffered saline (PBS) applied onto the other segment (n = 10) of the same pig. Results: Computer-based pathological morphometric analysis of stented coronary arteries, performed 4 weeks after stenting, demonstrated no significant difference in morphometric parameters such as in-stent neointimal area and % area stenosis between the AdTβ-ExR group and control (n = 7 for each). However the AdTβ-ExR group had increased neointimal cell density, infiltration of inflammatory cells mostly consisting of CD3 + T cell, accumulation of hyaluronan, cell proliferation rate, and adventitial matrix metalloproteinase-1 (MMP-1) expression compared with control. The expression of connective tissue growth factor mRNA, measured by reverse transcription PCR, in cultured rat arterial smooth muscle cells was inhibited by AdTβ-ExR at moi 60. Conclusions: Blockade of TGF-β by catheter-based local intravascular gene delivery does not reduce stent-induced neointima formation 4 weeks after stenting in spite of modest inhibition of ECM accumulation, but it induces vascular inflammation and associated pathological changes that may potentially aggravate lesion progression. © 2009 Elsevier Ireland Ltd. | * |
dc.language | English | * |
dc.title | Blockade of TGF-β by catheter-based local intravascular gene delivery does not alter the in-stent neointimal response, but enhances inflammation in pig coronary arteries | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 145 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 468 | * |
dc.relation.lastpage | 475 | * |
dc.relation.journaltitle | International Journal of Cardiology | * |
dc.identifier.doi | 10.1016/j.ijcard.2009.11.032 | * |
dc.identifier.wosid | WOS:000285136200025 | * |
dc.identifier.scopusid | 2-s2.0-78149349800 | * |
dc.author.google | Chung I.-M. | * |
dc.author.google | Kim J. | * |
dc.author.google | Pak Y.K. | * |
dc.author.google | Jang Y. | * |
dc.author.google | Yang W.-I. | * |
dc.author.google | Han I. | * |
dc.author.google | Park S.-J. | * |
dc.author.google | Park S.-W. | * |
dc.author.google | Huh J. | * |
dc.author.google | Wight T.N. | * |
dc.author.google | Ueno H. | * |
dc.contributor.scopusid | 정익모(7201867918) | * |
dc.date.modifydate | 20231116123346 | * |