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DNA core@Inorganic shell

Title
DNA core@Inorganic shell
Authors
Park D.-H.Kim J.-E.Oh J.-M.Shul Y.-G.Choy J.-H.
Ewha Authors
최진호
SCOPUS Author ID
최진호scopus
Issue Date
2010
Journal Title
Journal of the American Chemical Society
ISSN
0002-7863JCR Link
Citation
vol. 132, no. 47, pp. 16735 - 16736
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A chemically well-defined Bio Core@Inorganic Shell nanohybrid, which consists of rationally designed DNA molecule core with a size of ∼100 nm and spherical inorganic nanoshell with an overall thickness of ∼10 nm reassembled with exfoliated layered metal hydroxide (MH nanosheets), is prepared. The DNA encapsulation and its release, due to the pH-dependent solubility of the MH nanoshell, plays a crucial role in maximizing the stability of base sequence-manipulated and probe-functionalized DNA molecules with designed information. The present DNA Core@MH Shell nanohybrid can provide wide bioinspired applications converged with nanotechnology, such as an advanced gene delivery system and a biomedical diagnostics, tracing/collection/sensing system for DNA-based information. © 2010 American Chemical Society.
DOI
10.1021/ja105809e
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자연과학대학 > 화학·나노과학전공 > Journal papers
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