View : 14 Download: 0

Dynamic fluorescence imaging of indocyanine green for reliable and sensitive diagnosis of peripheral vascular insufficiency

Title
Dynamic fluorescence imaging of indocyanine green for reliable and sensitive diagnosis of peripheral vascular insufficiency
Authors
Kang Y.Lee J.Kwon K.Choi C.
Ewha Authors
권기환
SCOPUS Author ID
권기환scopus
Issue Date
2010
Journal Title
Microvascular Research
ISSN
0026-2862JCR Link
Citation
vol. 80, no. 3, pp. 552 - 555
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Quantitative measurement of functional tissue perfusion is essential for early diagnosis and proper treatment of peripheral arterial occlusive disease (PAOD). We have previously demonstrated that dynamic imaging of near-infrared fluorophore indocyanine green (ICG) can be a noninvasive and sensitive tool to measure tissue perfusion. In the present study, we investigated the clinical efficacy of ICG perfusion imaging method for the diagnosis of PAOD. Total nineteen PAOD patients and age-matched controls (n= 10) were evaluated for lower extremity tissue perfusion using ICG perfusion imaging. The perfusion rates of the lower extremities with severe PAOD (n= 25 legs, 16.6 ± 8.3%/min) were significantly lower than those of normal controls (38.1 ± 17.3%/min, p< 0.001). In cases of mild PAOD, the perfusion rates (n= 11 legs, 18.3 ± 10.3%/min) were also significantly lower compared to the control; while the conventional ankle-brachial index (ABI) test failed to detect mild functional impairment. These results collectively indicate that ICG perfusion imaging can be a very effective tool for diagnosis of PAOD with a superior efficacy in comparison to conventional ABI test. © 2010 Elsevier Inc.
DOI
10.1016/j.mvr.2010.07.004
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE