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Paraoxonase 1 gene and glutathione S-transferase μ 1 gene interaction with preterm delivery in Korean women

Title
Paraoxonase 1 gene and glutathione S-transferase μ 1 gene interaction with preterm delivery in Korean women
Authors
Lee B.E.Park H.Park E.A.Gwak H.Ha E.H.Pang M.-G.Kim Y.J.
Ewha Authors
하은희박은애김영주박혜숙곽혜선
SCOPUS Author ID
하은희scopus; 박은애scopus; 김영주scopus; 박혜숙scopus; 곽혜선scopus
Issue Date
2010
Journal Title
American Journal of Obstetrics and Gynecology
ISSN
0002-9378JCR Link
Citation
vol. 203, no. 6, pp. 5690 - 5690000000
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
OBJECTIVE: This study was undertaken to identify the paraoxonase 1 gene and glutathione S-transferase μ 1 gene interaction for the risk of preterm delivery and to determine the serum paraoxonase activity according to paraoxonase 1 genotypes. STUDY DESIGN: This case-control study was performed on 162 gravida women with preterm delivery and 306 controls. Serum paraoxonase activity was measured by a ultraviolet spectrophotometer. Logistic regression, 2-way analysis of variance, and multifactor dimensionality reduction analysis were used. RESULTS: Gravida women with the QQ and QR genotype of paraoxonase 1 with high body mass index had 6.19-and 4.41-fold increased risks of preterm delivery. The glutathione S-transferase μ 1 null genotype and the interaction between the paraoxonase 1 genotype and glutathione S-transferase μ 1 null type conferred a risk for preterm delivery. Serum paraoxonase activity was significantly different according to paraoxonase 1 genotypes (P < 0001). CONCLUSION: The glutathione S-transferase μ 1 null genotype confers a risk for preterm delivery in Korean gravida women independent of and interactive with the paraoxonase 1 genotype. © 2010 Mosby, Inc. All rights reserved.
DOI
10.1016/j.ajog.2010.07.029
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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