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Three phenotypes of obstructive lung disease in the elderly

Title
Three phenotypes of obstructive lung disease in the elderly
Authors
Jo K.-W.Ra S.W.Chae E.J.Seo J.B.Kim N.K.Lee J.-H.Kim E.-K.Lee Y.K.Kim T.-H.Huh J.W.Kim W.J.Lee J.H.Lee S.-M.Lim S.Y.Shin T.R.Yoon H.I.Sheen S.S.Lee J.S.Lee S.-D.Oh Y.-M.
Ewha Authors
이진화
SCOPUS Author ID
이진화scopus
Issue Date
2010
Journal Title
International Journal of Tuberculosis and Lung Disease
ISSN
1027-3719JCR Link
Citation
vol. 14, no. 11, pp. 1481 - 1488
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
SETTING: Eleven referring hospitals in South Korea. OBJECTIVE: To classify the phenotypes in elderly subjects with obstructive lung disease (OLD). METHODS: We analysed 191 subjects aged ≥60 years with chronic respiratory symptoms and either obstructive spirometry or bronchial hyperresponsiveness. Factor analysis was performed using commonly measured variables and revealed four significant variables: 1) the ratio of inspiratory capacity to total lung capacity, 2) the total score on the St George's Respiratory Questionnaire, 3) the volume fraction of the lung less than 950 Hounsfield Unit at full inspiration on volumetric computed tomography and 4) post-bronchodilator forced expiratory volume in 1 second (FEV1) changes. We performed a cluster analysis on these four variables. RESULTS: The mean age was 68.5 (±5.2 SD) years and the mean post-bronchodilator FEV1 was 52.4% (±16.5) predicted. Three clusters with the following phenotypes were identified: Cluster 1 included subjects with moderate to severe airflow obstruction and bronchodilator reversibility; Cluster 2 subjects had moderate airflow obstruction without bronchodilator reversibility, and Cluster 3 subjects had severe airflow obstruction without bronchodilator reversibility. CONCLUSIONS: We identified three phenotypes in elderly subjects with OLD. Follow-up studies are needed to explore the clinical significance of each phenotype. © 2010 The Union.
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의학전문대학원 > 의학과 > Journal papers
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