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Genetic variants that affect length/height in infancy/early childhood in Vietnamese-Korean families

Title
Genetic variants that affect length/height in infancy/early childhood in Vietnamese-Korean families
Authors
Kim H.-N.Lee E.-J.Jung S.-C.Lee J.-Y.Chung H.W.Kim H.-L.
Ewha Authors
김형래정혜원정성철김한나
SCOPUS Author ID
김형래scopus; 정혜원scopus; 정성철scopus; 김한나scopus
Issue Date
2010
Journal Title
Journal of Human Genetics
ISSN
1434-5161JCR Link
Citation
vol. 55, no. 10, pp. 681 - 690
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
To identify genetic factors that influence height in infancy/early childhood, a family-based genome-wide association study was conducted using 269 888 single-nucleotide polymorphisms (SNPs) in 165 families composed of a Korean father, a Vietnamese mother and Vietnamese-Korean offspring in the International Marriage-based Immigrant Cohort in Korea. In a single-SNP-based analysis, the six SNPs in or near genes MAF, MAGI2, BMP4 and PTPN7 showed consistent suggestive associations at all height standard deviation scores using Korean, World Health Organization and Vietnamese growth references. Analyzing the haplotypes for the genes, haplotype blocks were found to be significantly associated with height. Similar to the results of a contiguous haplotype analysis using tag SNPs as above, noncontiguous haplotypes of variable length also showed a significant association near the suspected loci. Our result suggests that height during infancy/early childhood may be regulated by genetic variations that differ from those of adults. © 2010 The Japan Society of Human Genetics All rights reserved.
DOI
10.1038/jhg.2010.88
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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