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Therapeutic effects of resveratrol during acute periods following experimental ischemic stroke

Title
Therapeutic effects of resveratrol during acute periods following experimental ischemic stroke
Authors
Shin J.A.Lee H.Lim Y.-K.Koh Y.Choi J.H.Park E.-M.
Ewha Authors
박은미최지하신진아
SCOPUS Author ID
박은미scopus; 최지하scopus; 신진아scopus
Issue Date
2010
Journal Title
Journal of Neuroimmunology
ISSN
0165-5728JCR Link
Citation
vol. 227, no. 41276, pp. 93 - 100
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We defined whether resveratrol administration during the acute phase of ischemic stroke reduces brain injury in mice. Infarct volumes were decreased significantly in both sexes with different doses of resveratrol (5. mg/kg for males and 1. mg/kg for females) administered 3. h after ischemic stroke. Administration of resveratrol 6. h after insult was also effective to decrease infarct volumes. Resveratrol suppressed expressions of IL-1β and TNF-α, microglial activation, and ROS production in the ischemic cortex. The findings suggest that the suppression of inflammation is partly associated with the neuroprotective effects of resveratrol, and resveratrol can be developed as a therapeutic drug for acute ischemic stroke. © 2010 Elsevier B.V.
DOI
10.1016/j.jneuroim.2010.06.017
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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