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Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors

Title
Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors
Authors
Song H.Oh S.-R.Lee H.-K.Han G.Kim J.-H.Chang H.W.Doh K.-E.Rhee H.-K.Choo H.-Y.P.
Ewha Authors
박혜영
SCOPUS Author ID
박혜영scopus
Issue Date
2010
Journal Title
Bioorganic and Medicinal Chemistry
ISSN
0968-0896JCR Link
Citation
vol. 18, no. 21, pp. 7580 - 7585
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
5-Lipoxygenase (5-LOX) is important enzyme in the biosynthesis of leukotrienes, and is a potential target in the treatment of asthma and allergy. We designed and synthesized a series of benzoxazoles and benzothiazoles as 5-LOX inhibitors. Fourteen compounds prepared showed the inhibition of LTC4 formation with IC 50 value of 0.12-23.88 μM. Also two compounds 2d and 2g showed improved airway hypersensitiveness. © 2010 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmc.2010.08.047
Appears in Collections:
약학대학 > 약학과 > Journal papers
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