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dc.contributor.author윤영대-
dc.date.accessioned2016-08-28T12:08:46Z-
dc.date.available2016-08-28T12:08:46Z-
dc.date.issued2010-
dc.identifier.issn0898-6568-
dc.identifier.otherOAK-6969-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/221096-
dc.description.abstractImproved treatment of EBV positive lymphoma depends on the identification of molecular mechanism underlying chemo-resistance. LMP1 is an essential transmembrane protein for EBV-induced immortalization of hematopoietic cells. Herein, we show that an oncogenic Pim-1 is translocated to the cytoplasm by LMP1. Three lines of evidence indicate that cytoplasmic sequestration of Pim-1 may be required for LMP1-induced cancer cell survival. First, Pim-1 enhanced the survival of LMP1-overexpressing cells treated with doxorubicin. Second, nuclear export of Pim-1 was sufficient to increase the survival. Third, knockdown of Pim-1 effectively suppressed LMP-1-induced survival of cancer cells. Collectively, these data suggest that Pim-1 is a downstream target of LMP1, and that it contributes to the chemo-resistance of cancer cells. © 2010 Elsevier Inc.-
dc.languageEnglish-
dc.titleEpstein-Barr virus latent membrane protein 1 increases chemo-resistance of cancer cells via cytoplasmic sequestration of Pim-1-
dc.typeArticle-
dc.relation.issue12-
dc.relation.volume22-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage1858-
dc.relation.lastpage1863-
dc.relation.journaltitleCellular Signalling-
dc.identifier.doi10.1016/j.cellsig.2010.07.013-
dc.identifier.wosidWOS:000282857200008-
dc.identifier.scopusid2-s2.0-77956546771-
dc.author.googleKim J.H.-
dc.author.googleKim W.S.-
dc.author.googleYun Y.-
dc.author.googlePark C.-
dc.contributor.scopusid윤영대(7201731033)-
dc.date.modifydate20200901081003-
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자연과학대학 > 생명과학전공 > Journal papers
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