Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 황은숙 | * |
dc.date.accessioned | 2016-08-28T12:08:45Z | - |
dc.date.available | 2016-08-28T12:08:45Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 0020-7136 | * |
dc.identifier.other | OAK-6950 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221082 | - |
dc.description.abstract | T-box-containing protein expressed in T cells (T-bet) is a master transcription factor for the development of interferon (IFN) γ-producing T helper 1 (Th1) cells and also functions in other immune cells including natural killer (NK), cytotoxic T lymphocytes and dendritic cells. T-bet-deficient mice increased susceptibility to viral infection and tumor development due to the defective functions of immune cells. T-bet is known to play a key role in NK-mediated antimetastatic response; however, it remains to be characterized whether T-bet is essential for in vivo tumor suppression mediated by T cells. Here, we have investigated in vivo tumor suppression effect of T-bet-restored T cells using T cell-specific and inducible T-bet transgenic mice generated in a T-bet-deficient background. T-bet-null mice increased susceptibility to tumor development, whereas induction of T cell-specific T-bet expression upon melanoma cell injection substantially suppressed tumor development by inducing IFNγ production in T cells and tumor cell apoptosis. Late induction of T-bet expression in tumor-bearing mice produced comparable amounts of IFNγ with control and significantly decreased tumor volume. In addition, increased melanoma lung metastasis in T-bet-deficient mice was strikingly inhibited by T-bet restoration in T cells. Intravenous injection of activated Th1 cells, not T-bet-null Th1 cells, attenuated metastatic melanoma progression, in addition, restoration of T-bet in T-bet-null Th1 cells certainly retrieved antimetastatic activity. These results suggest that T-bet expression in T cells is crucial for the control of tumor development and antimetastatic activity. © 2010 UICC. | * |
dc.language | English | * |
dc.title | In vivo tumor suppression activity by T cell-specific T-bet restoration | * |
dc.type | Article | * |
dc.relation.issue | 9 | * |
dc.relation.volume | 127 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 2129 | * |
dc.relation.lastpage | 2137 | * |
dc.relation.journaltitle | International Journal of Cancer | * |
dc.identifier.doi | 10.1002/ijc.25238 | * |
dc.identifier.wosid | WOS:000282539600014 | * |
dc.identifier.scopusid | 2-s2.0-77956642612 | * |
dc.author.google | Lee K. | * |
dc.author.google | Min H.J. | * |
dc.author.google | Jang E.J. | * |
dc.author.google | Hong J.-H. | * |
dc.author.google | Hwang E.S. | * |
dc.contributor.scopusid | 황은숙(8688011100) | * |
dc.date.modifydate | 20240123102458 | * |