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dc.contributor.author김승철-
dc.contributor.author주웅-
dc.contributor.author이사라-
dc.date.accessioned2016-08-28T12:08:43Z-
dc.date.available2016-08-28T12:08:43Z-
dc.date.issued2010-
dc.identifier.issn2005-0380-
dc.identifier.otherOAK-6929-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/221067-
dc.description.abstractObjective: The goal of this study was to investigate the relationship between plasma levels of insulin-like growth factors-1 (IGF-1) and IGF-binding protein-3 (IGFBP-3) and the risk for cervical intraepithelial neoplasia (CIN) and cervical cancer. Methods: Plasma levels of IGF-1 and IGFBP-3 of 44 cervical cancer patients, 82 CIN patients and 40 neoplasm-free patients were investigated. Then the associations of the plasma levels of IGF-1 and IGFBP-3 with cervical neoplasm or its clinicopathologic parameters were analyzed. Results: The mean IGF-1 concentrations were significantly different among the control, CIN, and cervical cancer groups; the levels were higher in the CIN group compared to the controls. According to the quartile category, the plasma IGF-1 level was significantly higher (p=0.0015) in the CIN group than in the controls. The IGFBP-3 level showed no association between the controls and CIN groups (p=0.842). Although the mean IGF-1/IGFBP-3 molar ratio had borderline significance (p=0.08) among the study population, the quartile comparison showed a significantly higher IGF-1/IGFBP-3 molar ratio in the CIN group compared to the control group (p=0.041). Conclusion: Plasma levels of IGF-1 and the IGF-1/IGFBP-3 molar ratio might be useful for the development early detection of cervical lesions and used as an adjuvant diagnostic tool for cervical neoplasia after more larger scale research.-
dc.languageEnglish-
dc.titlePlasma levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in women with cervical neoplasia-
dc.typeArticle-
dc.relation.issue3-
dc.relation.volume21-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.indexKCI-
dc.relation.startpage174-
dc.relation.lastpage180-
dc.relation.journaltitleJournal of Gynecologic Oncology-
dc.identifier.doi10.3802/jgo.2010.21.3.174-
dc.identifier.wosidWOS:000282303800006-
dc.identifier.scopusid2-s2.0-78049452917-
dc.author.googleLee S.W.-
dc.author.googleLee S.Y.-
dc.author.googleLee S.R.-
dc.author.googleJu W.-
dc.author.googleKim S.C.-
dc.contributor.scopusid김승철(35264000100)-
dc.contributor.scopusid주웅(8873659700)-
dc.contributor.scopusid이사라(17343827300)-
dc.date.modifydate20190301081000-
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의과대학 > 의학과 > Journal papers
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