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Biosynthesis of plant-specific flavones and flavonols in Streptomyces venezuelae

Title
Biosynthesis of plant-specific flavones and flavonols in Streptomyces venezuelae
Authors
Park S.R.Paik J.H.Ahn M.S.Park J.W.Yoon Y.J.
Ewha Authors
윤여준박제원
SCOPUS Author ID
윤여준scopus
Issue Date
2010
Journal Title
Journal of Microbiology and Biotechnology
ISSN
1017-7825JCR Link
Citation
vol. 20, no. 9, pp. 1295 - 1299
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Recently, recombinant Streptomyces venezuelae has been established as a heterologous host for microbial production of flavanones and stilbenes, a class of plant-specific polyketides. In the present work, we expanded the applicability of the S. venezuelae system to the production of more diverse plant polyketides including flavones and flavonols. A plasmid with the synthetic codon-optimized flavone synthase I gene from Petroselium crispum was introduced to S. venezuelae DHS2001 bearing a deletion of the native pikromycin polyketide synthase gene, and the resulting strain generated flavones from exogenously fed flavanones. In addition, a recombinant S. venezuelae mutant expressing a codon-optimized flavanone 3β-hydroxylase gene from Citrus siensis and a flavonol synthase gene from Citrus unshius also successfully produced flavonols.
DOI
10.4014/jmb.1005.05038
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자연과학대학 > 화학·나노과학전공 > Journal papers
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