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Acute myeloid leukemia associated with t(10;17)(p13-15;q12-21) and phagocytic activity by leukemic blasts: A clinical study and review of the literature
- Acute myeloid leukemia associated with t(10;17)(p13-15;q12-21) and phagocytic activity by leukemic blasts: A clinical study and review of the literature
- Oh S.H.; Park T.S.; Cho S.Y.; Kim M.J.; Huh J.; Kim B.; Song S.A.; Lee J.Y.; Jun K.R.; Shin J.H.; Kim H.R.; Lee J.N.
- Ewha Authors
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- Cancer Genetics and Cytogenetics
- vol. 202, no. 1, pp. 43 - 46
- Translocation (10;17)(p13-15;q12-21) in acute leukemia is rarely reported in the literature. Here, we present both a novel t(10;17) case study and a review of relevant literature on t(10;17) in acute leukemia (10 cases). In summary, we came to the following preliminary conclusions: t(10;17) is associated with poorly differentiated acute leukemia subtype [90%; eight cases of acute myeloid leukemia (AML M0, M1) and one case of acute undifferentiated leukemia], phagocytic activity by blasts occurs (30%), and the survival time was short in three of the seven t(10;17) cases for whom follow-up data were available (median, 8 months). More clinical studies concerning the prognosis, treatment response, and survival of patients with t(10;17) are necessary. © 2010 Elsevier Inc.
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