Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 전길자 | * |
dc.contributor.author | 이영미 | * |
dc.date.accessioned | 2016-08-28T12:08:39Z | - |
dc.date.available | 2016-08-28T12:08:39Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 0003-2700 | * |
dc.identifier.other | OAK-6867 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221027 | - |
dc.description.abstract | This paper reports a real-time study of the codynamical changes in the release of endogenous nitric oxide (NO) and oxygen (O 2) consumption in a rat neocortex in vivo upon electrical stimulation using an amperometric NO/O 2 dual microsensor. Electrical stimulation induced transient cerebral hypoxia due to the increased metabolic demands that were not met by the blood volume inside the stimulated cortical region. A NO/O 2 dual microsensor was successfully used to monitor the pair of real-time dynamic changes in the tissue NO and O 2 contents. At the onset of electrical stimulation, there was an immediate decrease in the cortical tissue O 2 followed by a subsequent increase in the cortical tissue NO content. The averages of the maximum normalized concentration changes induced by the stimulation were a 0.41 (±0.04)-fold decrease in the O 2 and a 3.6 (±0.9)-fold increase in the NO concentrations when compared with the corresponding normalized basal levels. The peak increase in NO was always preceded by the peak decrease in O 2 in all animals (n = 11). The delay between the maximum decrease in O 2 and the maximum increase in NO varied from 3.1 to 54.8 s. This rather wide variation in the temporal associations was presumably attributed to the sparse distribution of NOS-containing neurons and the individual animal's differences in brain vasculatures, which suggests that a sensor with fine spatial resolution is needed to measure the location-specific real-time NO and O 2 contents. In summary, the developed NO/O 2 dual microsensor is effective for measuring the NO and O 2 contents in vivo. This study provides direct support for the dynamic role of NO in regulating the cerebral hemodynamics, particularly related to the tissue oxygenation. © 2010 American Chemical Society. | * |
dc.language | English | * |
dc.title | Real-time in vivo simultaneous measurements of nitric oxide and oxygen using an amperometric dual microsensor | * |
dc.type | Article | * |
dc.relation.issue | 18 | * |
dc.relation.volume | 82 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 7618 | * |
dc.relation.lastpage | 7624 | * |
dc.relation.journaltitle | Analytical Chemistry | * |
dc.identifier.doi | 10.1021/ac1013496 | * |
dc.identifier.wosid | WOS:000281710900014 | * |
dc.identifier.scopusid | 2-s2.0-77956604559 | * |
dc.author.google | Park S.S. | * |
dc.author.google | Hong M. | * |
dc.author.google | Song C.-K. | * |
dc.author.google | Jhon G.-J. | * |
dc.author.google | Lee Y. | * |
dc.author.google | Suh M. | * |
dc.contributor.scopusid | 전길자(6701488476) | * |
dc.contributor.scopusid | 이영미(35237907700) | * |
dc.date.modifydate | 20240123112016 | * |