Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오구택 | * |
dc.contributor.author | 손성근 | * |
dc.contributor.author | 이미니 | * |
dc.date.accessioned | 2016-08-28T12:08:37Z | - |
dc.date.available | 2016-08-28T12:08:37Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 0021-9150 | * |
dc.identifier.other | OAK-6839 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221006 | - |
dc.description.abstract | Cyclooxygenase (COX) and 5-lipoxygenase (5-LOX), which play pivotal roles in atherogenesis, have been reported to be involved in plaque stability. Licofelone, a dual COX and 5-LOX inhibitor, has been reported to possess anti-atherogenic effect in rabbit atherosclerosis model. We therefore investigated the anti-atherogenic effect of BHB-TZD [5-(3,5-di-tert-butyl-4-hydroxybenzylidene)thiazolidin-2,4-dione], a dual COX and 5-LOX inhibitor, in low density lipoprotein receptor null (LDLR-/-) mice. Fifteen LDLR-/- mice were fed a western diet (control group), whereas 15 were fed a western diet plus 0.1% (w/w) BHB-TZD (BHB-TZD group). After 8 weeks, the BHB-TZD group had markedly lower serum levels of leukotriene B4 and prostaglandin E2 than the control group. Interestingly, BHB-TZD treatment also reduced plasma triglyceride level without significant changes in total cholesterol and HDL levels. Compared with control mice, BHB-TZD fed mice had 52% fewer fatty streak lesions in the aortic sinus, as well as fewer initial lesions in the aortic arch. Macrophage infiltration into the lesions was 40% lower, and collagen and smooth muscle cells were increased by 102% and 96%, respectively, in the BHB-TZD group compared with the control group. In addition, aortic expression of proatherogenic molecules including TNF-α, IL-1β, IL-6, MCP-1 and VCAM-1, was lower in the BHB-TZD group than the control group. BHB-TZD treatment also reduced MMP-2 and MMP-9 expressions in aorta. In conclusion, BHB-TZD effectively attenuated atherosclerosis in mouse model, suggesting its therapeutic potential for atherosclerosis. © 2010 Elsevier Ireland Ltd. | * |
dc.language | English | * |
dc.title | Anti-atherogenic effect of BHB-TZD having inhibitory activities on cyclooxygenase and 5-lipoxygenase in hyperlipidemic mice | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 212 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 146 | * |
dc.relation.lastpage | 152 | * |
dc.relation.journaltitle | Atherosclerosis | * |
dc.identifier.doi | 10.1016/j.atherosclerosis.2010.05.003 | * |
dc.identifier.wosid | WOS:000281459900023 | * |
dc.identifier.scopusid | 2-s2.0-77956232311 | * |
dc.author.google | Choi J.-H. | * |
dc.author.google | Jeon H.J. | * |
dc.author.google | Park J.-G. | * |
dc.author.google | Sonn S.K. | * |
dc.author.google | Lee M.-R. | * |
dc.author.google | Lee M.-N. | * |
dc.author.google | You H.J. | * |
dc.author.google | Kim G.-Y. | * |
dc.author.google | Kim J.-H. | * |
dc.author.google | Lee M.H. | * |
dc.author.google | Kwon O.-S. | * |
dc.author.google | Nam K.-H. | * |
dc.author.google | Kim H.-C. | * |
dc.author.google | Jeong T.-S. | * |
dc.author.google | Lee W.S. | * |
dc.author.google | Oh G.T. | * |
dc.contributor.scopusid | 오구택(7007056663) | * |
dc.contributor.scopusid | 손성근(8628610900) | * |
dc.contributor.scopusid | 이미니(35285954900;56136972000) | * |
dc.date.modifydate | 20240123094756 | * |