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Effects of scoparone on dopamine release in PC12 cells

Title
Effects of scoparone on dopamine release in PC12 cells
Authors
Yang Y.J.Lee H.J.Lee B.K.Lim S.C.Lee C.K.Lee M.K.
Ewha Authors
이병구
SCOPUS Author ID
이병구scopusscopus
Issue Date
2010
Journal Title
Fitoterapia
ISSN
0367-326XJCR Link
Citation
vol. 81, no. 6, pp. 497 - 502
Indexed
SCIE; SCOPUS WOS scopus
Abstract
The effects of scoparone on dopamine release in PC12 cells were investigated. Scoparone at 50-200 μM increased dopamine release into the culture medium. However, the released levels of dopamine by scoparone were not altered in the absence of extracellular Ca 2+ and by adenylyl cyclase inhibitor MDL-12,330A. Scoparone increased phosphorylation of PKA, CaMK II and synapsin I. Scoparone also enhanced K +-induced levels of dopamine release by CaMK II phosphorylation. These results suggest that scoparone increases dopamine release by synapsin I phosphorylation via activation of PKA and CaMK II, which are mediated by cyclic AMP levels and Ca 2+ influx. © 2010 Elsevier B.V. All rights reserved.
DOI
10.1016/j.fitote.2010.01.003
Appears in Collections:
약학대학 > 약학과 > Journal papers
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