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Seizure exacerbation and hormonal cycles in women with epilepsy

Title
Seizure exacerbation and hormonal cycles in women with epilepsy
Authors
Kim G.H.Lee H.W.Park H.Lee S.K.Lee S.A.Kim Y.I.Song H.K.Shin D.J.Hong S.B.
Ewha Authors
박혜숙이향운김건하
SCOPUS Author ID
박혜숙scopus; 이향운scopus; 김건하scopus
Issue Date
2010
Journal Title
Epilepsy Research
ISSN
0920-1211JCR Link
Citation
vol. 90, no. 3, pp. 214 - 220
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Purpose: To investigate seizure frequency in relation to menstrual cycles and seizure exacerbations with respect to various clinical factors in women with epilepsy. Methods: The authors prospectively evaluated premenopausal women with epilepsy aged 15-44. Catamenial epilepsy was defined as seizure frequency during the perimenstrual (C1), periovulatory (C2) or non-menstrual phase (C3) at least twice that during other phases. Results: In total 255 menstrual cycles, 231 ovulatory and 24 anovulatory cycles were registered in 79 patients (29.7 ± 7.8 years old). Average seizure frequency was 0.13 ± 0.29/day during the menstrual phase, 0.14 ± 0.24 during the follicular, 0.18 ± 0.61 in the ovulatory, and 0.14 ± 0.33 during the luteal phases. Catamenial seizure exacerbation was observed in 37/79 (46.8%) patients and 108/255 (42.4%) cycles, more frequently during anovulatory (17/24, 70.8%) than ovulatory (91/231, 39.4%) cycles (p=0.003). During ovulatory cycles, seizure exacerbation was primarily C1 (42.9%) or C2 (45.1%) pattern. Myoclonic seizures were more frequently associated with the C1 pattern. Conclusions: Overall, 46.8% of women had catamenial epilepsy. Seizure frequencies were greater during menstrual and ovulatory phases for ovulatory cycles, and during non-menstrual phases for anovulatory cycles. © 2010 Elsevier B.V.
DOI
10.1016/j.eplepsyres.2010.05.003
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의학전문대학원 > 의학과 > Journal papers
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